THE EFFECT OF β-ADRENOCEPTOR BLOCKERS ON THE ABSORPTION AND EXCRETION OF CHLOROTHIAZIDE IN MAN |
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Authors: | G. I. Adebayo A. B. Oyenuga A. F. B. Mabadeje |
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Affiliation: | Department of Pharmacology, College of Medicine, University of Lagos, PMB 12003, Lagos, Nigeria |
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Abstract: | The effect of beta-adrenoceptor blockers on the absorption and elimination of the diuretic chlorothiazide was studied in healthy subjects. A week of pretreatment with either pindolol (10 mg twice daily) or propranolol (80 mg twice daily) resulted in significant reduction in 36 h mean cumulative urinary recovery of chlorothiazide in two groups of six subjects compared with a control (untreated) group. A week of pretreatment with atenolol (100 mg daily) did not significantly alter 36 h cumulative urinary excretion in another group of six subjects. None of the beta-blockers significantly changed chlorothiazide half-life. It is suggested that the non-selective (as opposed to the cardioselective) beta-blockers reduce chlorothiazide absorption by the mechanism(s) discussed. |
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Keywords: | β-adrenoceptor blockers atenolol chlorothiazide pindolol propranolol. |
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