川崎病患儿血浆D-二聚体的变化及临床意义

目的探讨川崎病-二聚体急性期变化和对冠状动脉损伤（CAL）的诊断价值。方法收集50例川崎病患儿（KD组）和32例健康儿童（对照组）治疗前空腹静脉血标本，检测血浆D-二聚体水平，分析其与冠状动脉损伤的关系。结果KD组血清D-二聚体含量为（0．51±0．13）mg／L，对照组为（0．14±0．07）mg／L，KD组含量高于对照组，差异有统计学意义（P〈0．05）；KD组患儿中，冠状动脉病变组（CAL组）血清D-二聚体含量为（0．56±0．16）mg／L，非冠状动脉病变组（NCAL组）为（0．45±0．12）mg／L，CAL组含量高于NCAL组，差异有统计学意义（P〈0．05）。结论川崎病急性期血浆D-二聚体水平明显升高，检测D-二聚体对川崎病的早期诊断与判断冠状动脉损伤具有一定价值。

Change and Clinical Significance of D-dimer in Children with Kawasaki Disease

Objectives To explore the changes of D-dimer in children with Kawasaki Disease（KD） and analyse its relationship to coronary artery disease（CAL）. Methods We collected 50 cases of KD and 32 cases of healthy children as negative control. The level of D-dimer in plasma was tested before treatment to survey the relationship between D-dimer and coronary artery injury. Results The level of D-dimer in KD group was （0.51 ±0.13）mg/L and （0.14 ± 0.07）mg/L in nagtive control. There was a significant difference between the two groups （P〈0.05）. In KD group, the level of D-dimer in CAL was （0.56 ± 0.16）mg/L and （0.45 ± 0.12）mg/L in NCAL. There was a significant difference between CAL an NCAL （P〈0.05）. Conclusion In acute phase of Kawasaki disease, the level of D-dimer was higher obviously. It was useful to make a early diagnose to KD and CAL.