| 低分子肝素对冠心病患者组织因子途径抑制物的影响 |
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| 引用本文： | 陈晓于,陈灿,陈建英,回皓升,杨勤.低分子肝素对冠心病患者组织因子途径抑制物的影响[J].中国综合临床,2004,20(1):15-16. |
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| 作者姓名： | 陈晓于 陈灿 陈建英 回皓升 杨勤 |
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| 作者单位： | 524001,湛江,广东医学院附属医院心内科 |
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| 摘 要： | 目的 探讨冠状动脉粥样硬化性心脏病(CHD)患者组织因子途径抑制物(TFPI)和组织因子(TE)的变化以及低分子肝素对其影响。方法 采用酶联免疫吸附法测定22例稳定型心绞痛(SA)，20例不稳定型心绞痛(UA)患者及18例急性心肌梗死(AMI)患者低分子肝素治疗前后TF及TFPI的变化。结果 CHD患者低分子肝素治疗前TF及TFPI比健康对照组显著增高，TFPI／FT比值较健康对照组显著降低；经治疗后，TF较治疗前显著下降，而TFPI显著增高，TFPI／TF比值较治疗前显著增高。结论 CHD存在凝血功能的亢进，TFPI是一种新的抗凝物质，低分子肝素能加强其作用。
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| 关 键 词： | 冠状动脉疾病 低分子肝素 组织因子 |
| 文章编号： | 1008-6315(2004)01-0015-02 |
| 修稿时间： | 2003年6月17日 |
The effect of low molecular weight heparin on plasma tissue factor pathway inhibitor in coronary atherosclesis heart disease patients |
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| Chen Xiaoyu,Chen Can,Chen Jianying,et al..The effect of low molecular weight heparin on plasma tissue factor pathway inhibitor in coronary atherosclesis heart disease patients[J].Clinical Medicine of China,2004,20(1):15-16. |
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| Authors: | Chen Xiaoyu Chen Can Chen Jianying |
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| Institution: | 524001 Guangdong |
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| Abstract: | Objective To observe the effect of low molecular weight heparin on tissue factor pathway inhibitor(TFPI) and tissue factor(TF) in coronary atherosclesis heart disease(CHD) patients as well as their changes. Methods TF and TFPI were detected by ELISA in 22 cases of stable angina pectos(SA),20 cases of unstable angina pectos(US) and 18 cases of acute myocardial infarction(AMI). Results Levels of TF and TFPI were high in patients with CHD compared with normal controls. TFPI/TF was lower in patients with CHD than controls. After treatment by low molecular weight heparin,TF decreased significantly while TFPI increased significantly,and TFPI/TF significantly increased. Conclusion The hyperactivation of blood coagulation exists in CHD. TFPI is a new anti-coagulation material which is strengthened by low molecular weight heparin. |
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| Keywords: | Coronary heart disease Low molecular weight heparin Tissue factor |
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