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| 手性毛细管柱气相色谱法测定冰硼散中冰片的含量 | |
| 引用本文： | 付滢舟,冯有龙,曹玲,王玉.手性毛细管柱气相色谱法测定冰硼散中冰片的含量[J].中南药学,2012,10(1):19-22. |
| 作者姓名： | 付滢舟 冯有龙 曹玲 王玉 |
| 作者单位： | 1. 中国药科大学,南京,210009 2. 江苏省食品药品检验所,南京,210008 3. 中国药科大学,南京210009;江苏省食品药品检验所,南京210008 |
| 摘 要： | 目的 建立手性毛细管柱气相色谱法同时测定冰硼散中异龙脑、左旋龙脑、右旋龙脑的含量.方法 采用气相色谱法、手性毛细管柱；柱温为120℃；进样口温度200℃；检测器温度220℃.结果 右旋龙脑在0.01～0.39 mg· mL-1与峰面积线性关系良好,r=0.999 9；左旋龙脑在0.01～0.38 mg·mL-1与峰面积线性关系良好,r=1.000 0；异龙脑在0.01～0.40 mg·mL-1与峰面积线性关系良好,r=1.000 0.结论 该方法快速,准确,精密度高,可测定以各种“冰片”投料生产的冰硼散中冰片的含量. |
| 关 键 词： | 右旋龙脑 手性柱 冰片 异龙脑 毛细管气相色谱法 左旋龙脑 |
Determination of borneol in Bingpengsan by chiral capillary GC |
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| FU Ying-zhou , FENG You-long , CAO Ling , WANG Yu.Determination of borneol in Bingpengsan by chiral capillary GC[J].Central South Pharmacy,2012,10(1):19-22. | |
| Authors: | FU Ying-zhou FENG You-long CAO Ling WANG Yu |
| Institution: | 1,2*(1.China Pharmaceutical University,Nanjing 210009;2.Jiangsu Institute for Food and Drug Control,Nanjing 210008) |
| Abstract: | Objective To establish a GC method to determine isoborneol,L-borneol and D-borneol simultaneously in Bingpengsan. Methods A chiral capillary column was used.The temperature of the column,inlet port and detector was 120 ℃,200 ℃ and 220 ℃,respectively. Results The linearity was 0.01-0.39 mg·mL-1 for D-borneol(r=0.999 9),0.01-0.38 mg·mL-1 for L-borneol(r=1.000 0),and 0.01-0.40 mg·mL-1 for isoborneol(r=1.000 0),respectively. Conclusion This method can be applied to determine various kinds of borneol in Bingpengsan quickly and accurately. |
| Keywords: | D-borneol chiral column borneol isoborneol capillary gas chromatography L-borneol |
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