| 注射用氯诺昔康与甲磺酸罗哌卡因注射液的配伍相容性研究 |
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| 引用本文： | 方宝霞,陈富超,于琳,李鹏,钱浓,朱西京.注射用氯诺昔康与甲磺酸罗哌卡因注射液的配伍相容性研究[J].中南药学,2012,10(10):749-752. |
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| 作者姓名： | 方宝霞 陈富超 于琳 李鹏 钱浓 朱西京 |
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| 作者单位： | 1. 湖北医药学院附属东风医院药学部,湖北十堰,442008
2. 湖北医药学院药学院学生,湖北十堰,442000 |
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| 基金项目： | 十堰市科学技术研究与开发计划项目(编号:2010st45) |
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| 摘 要： | 目的 考察注射用氯诺昔康与甲磺酸罗哌卡因注射液在0.9％氯化钠注射液中的配伍稳定性.方法 在室温条件下,采用高效液相色谱法测定配伍液48 h内氯诺昔康与甲磺酸罗哌卡因的含量变化,并观察配伍液的外观及pH值变化.结果 配伍液48 h内氯诺昔康与甲磺酸罗哌卡因的含量不断下降,并且配伍液在2h后出现沉淀.结论 室温条件下,注射用氯诺昔康与甲磺酸罗哌卡因注射液在0.9％氯化钠注射液中不稳定,临床不宜配伍应用.
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| 关 键 词： | 氯诺昔康 罗哌卡因 高效液相色谱法 配伍相容性 |
Stability and compatibility of lornoxicam with ropivacaine mesylate in 0.9% sodium chloride injection |
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| FANG Bao-xia
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CHEN Fu-chao
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YU Lin
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LI Peng
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QIAN Nong
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ZHU Xi-jing.Stability and compatibility of lornoxicam with ropivacaine mesylate in 0.9% sodium chloride injection[J].Central South Pharmacy,2012,10(10):749-752. |
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| Authors: | FANG Bao-xia CHEN Fu-chao YU Lin LI Peng QIAN Nong ZHU Xi-jing |
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| Institution: | 1.Department of Pharmacy,Dongfeng Hospital Affiliated with Hubei University of Medicine,Shiyan Hubei 442008;2.Pharmacy College of Hubei University of Medicine,Shiyan Hubei 442008) |
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| Abstract: | Objective To investigate the stability and compatibility of lornoxicam with ropivacaine mesylate in 0.9% sodium chloride injection.Methods An HPLC method was used to study the change of content after combination of lornoxicam with ropivacaine mesylate in 0.9% sodium chloride injection under ambient temperature within 48 h,and the appearance was observed and its pH value was determined.Results The contents of lornoxicam and ropivacaine mesylate steadily declined with precipitation at 2 h.Conclusion Lornoxicam with ropivacaine mesylate in 0.9% sodium chloride injection at ambient temperature is not stable,so clinical application should be avoided. |
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| Keywords: | lornoxicam ropivacaine HPLC compatibility |
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