CYP2E1基因1019位点多态性与肺癌易感性的Meta分析

目的：研究CYP2E1基因1019位点多态性与肺癌易感性的关系。方法：检索数据库,按纳入标准进行筛选,对纳入文献用Review Manager 4.2软件进行Meta分析,得到合并OR值（95%CI）,并进行一致性检验及发表偏倚检验。结果：共纳入文献11篇,累积病例1 278例,对照1 568例,与野生纯合基因型c1c1相比较,突变杂合基因型c1c2、突变纯合基因型c2c2和（c1c2＋c2c2）合并的OR值分别为0.74（0.63,0.87）、0.90（0.63,1.28）和0.73（0.63,0.86）。结论：CYP2E1基因1019位点c2突变子是肺癌的保护因素。

CYP2E1 gene 1019 polymorphism and the risk on human lung cancer:a Meta-analysis

Objective To explore the association between CYP2E1 codon 1019 polymorphism and the risk on human lung cancer.MethodsData bases were searched to select the references consistent with the criteria.Meta-analysis was performed by review manager 4.2 for pool OR value(with 95%CI),the heterogeneity was examined,a funnel plot and Egger’s linear regression method was constructed to check for publication bias,cumulative meta-analysis was also performed.Results A total of 11 case-control studies were collected including 1278 cases and 1568 controls.Compared with the wide-type homozygote c1/c1,the pooled OR value(with 95%CI) of c1c2、c2c2 and(c1c2+c2c2) were 0.74(0.63,0.87),0.90(0.63,1.28) and 0.73(0.63,0.86).Conclusion The c2 mutation on the codon 1019 of CYP2E1 gene was a protective factor.