| TE-01静脉注射乳剂的制备及处方工艺优化 |
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| 引用本文： | 孙子杭,胡凯莉,胡红霞,徐玮,王燕飞,涂亮星,奉建芳.TE-01静脉注射乳剂的制备及处方工艺优化[J].中南药学,2012,10(4):241-244. |
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| 作者姓名： | 孙子杭 胡凯莉 胡红霞 徐玮 王燕飞 涂亮星 奉建芳 |
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| 作者单位： | 1. 上海中医药大学穆拉德中药现代化研究中心,上海,201203
2. 武汉同源药业有限公司研究所,武汉,430074 |
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| 摘 要： | 目的 制备TE-01静脉注射乳剂并进行处方工艺优化.方法 采用高压均质方法制备TE-01乳剂,并通过正交设计优选TE-01静脉注射乳剂的最佳处方及其制备工艺.结果 TE-01静脉注射乳剂最佳处方及工艺为蛋黄卵磷脂含量1.2％,分散转速16 000 r·min-1,均质压力550 bar.结论 高压均质法可以制备出性质稳定的TE-01乳剂.
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| 关 键 词： | TE-01 静脉注射乳剂 处方工艺优化 |
Preparation and formulation optimization of TE-01 intravenous emulsion |
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| SUN Zi-hang
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HU Kai-li
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HU Hong-xia
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XU Wei
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WANG Yan-fei
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TU Liang-xing
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FENG Jian-fang.Preparation and formulation optimization of TE-01 intravenous emulsion[J].Central South Pharmacy,2012,10(4):241-244. |
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| Authors: | SUN Zi-hang HU Kai-li HU Hong-xia XU Wei WANG Yan-fei TU Liang-xing FENG Jian-fang |
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| Institution: | 1(1.Murad Research Center for Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203;2.Institute of Wuhan Tongyuan Pharmaceutical Ltd.,Wuhan 430074) |
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| Abstract: | Objective To prepare and optimize the formulation and preparation procedure of TE-01 intravenous emulsion.Methods High pressure homogenization method was used to prepare TE-01 intravenous emulsion.The formulation and preparation procedure of TE-01 intravenous emulsion were optimized by orthogonal experiments.Results The optimal formulation consisted of 1.2 % lecithin phospholipids with the dispersion rate at 16 000 r·min-1,and the homogenization pressure was 550 bar.Conclusion Stable TE-01 emulsion can be prepared by high pressure homogenization method. |
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| Keywords: | TE-01 intravenous emulsion formulation optimization |
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