| 注射用头孢地秦钠与注射用氯诺昔康配伍稳定性考察 |
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| 引用本文： | 陈富超,方宝霞,朱军,李鹏,杨盼鑫. 注射用头孢地秦钠与注射用氯诺昔康配伍稳定性考察[J]. 中南药学, 2012, 10(5): 364-367 |
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| 作者姓名： | 陈富超 方宝霞 朱军 李鹏 杨盼鑫 |
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| 作者单位： | 1. 湖北医药学院附属东风医院药学部,湖北十堰,442008
2. 湖北医药学院药学院,湖北十堰,442000 |
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| 摘 要： | 目的 考察注射用头孢地秦钠与注射用氯诺昔康在0.9％氯化钠注射液中的配伍稳定性.方法 在(25±1)℃下,采用高效液相色谱法(HPLC)测定配伍液8h内头孢地秦钠与氯诺昔康的含量变化,并观察和检测配伍液的外观、pH值及不溶性微粒变化,结果 在室温下配伍液8h内的含量、pH、不溶性微粒及外观均无明显变化.结论 室温条件下,注射用头孢地秦钠与注射用氯诺昔康在0.9％氯化钠注射液中8h内稳定.
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| 关 键 词： | 头孢地秦钠 氯诺昔康 高效液相色谱法 配伍 稳定性 |
Compatible stability of cefodizime sodium and lornoxicam in 0.9% sodium chloride |
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| CHEN Fu-chao , FANG Bao-xia , ZHU Jun , LI Peng , YANG Pan-xin. Compatible stability of cefodizime sodium and lornoxicam in 0.9% sodium chloride[J]. Central South Pharmacy, 2012, 10(5): 364-367 |
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| Authors: | CHEN Fu-chao FANG Bao-xia ZHU Jun LI Peng YANG Pan-xin |
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| Affiliation: | 1.Department of Pharmacy,Dongfeng Hospital Affiliated to Hubei University of Medicine,Shiyan Hubei 442008;2.College of Pharmacy,Hubei University of Medicine,Shiyan Hubei 442000) |
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| Abstract: | Objective To determine the stability and compatibility of cefodizime sodium with lornoxicam in 0.9% sodium chloride injection.Methods HPLC method was used to determine the change of content after combination of cefodizime sodium with lornoxicam in 0.9% sodium chloride injection under(25±1) ℃ within 8 h.The appearance and particle of the solution were observed and the pH value was measured.Results No significant differences were found in the content,appearance,particle and pH value of the mixture within 8 h at room temperature.Conclusion The mixture of cefodizime sodium with lornoxicam in 0.9% sodium chloride injection at room temperature is stable within 8 h. |
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| Keywords: | cefodizime sodium lornoxicam HPLC compatibility stability |
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