Event-related desynchronization of motor cortical oscillations in patients with multiple system atrophy |
| |
| Authors: | Ron Levy Andres M. Lozano Anthony E. Lang Jonathan O. Dostrovsky |
| |
| Affiliation: | (1) Division of Neurosurgery, Department of Clinical Neuroscience, Faculty of Medicine, University of Calgary, Foothills Medical Centre, Calgary, AB, T2N 2T9, Canada;(2) The Toronto Western Research Institute, 399 Bathurst St., Toronto, ON, M5T 2S8, Canada;(3) Department of Surgery, University of Toronto, Division of Neurosurgery, The Toronto Western Hospital, 399 Bathurst St., Toronto, ON, M5T 2S8, Canada;(4) Department of Medicine, University of Toronto, Division of Neurology, The Toronto Western Hospital, 399 Bathurst St., Toronto, ON, M5T 2S8, Canada;(5) Department of Physiology, Faculty of Medicine, University of Toronto, Rm. 3302 Medical Sciences Building, 1 King’s College Circle, Toronto, ON, M5S 1A8, Canada; |
| |
| Abstract: | Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by parkinsonism (MSA-P), cerebellar and autonomic deficits. In Parkinson’s disease (PD), an impaired modulation of motor cortical mu and beta range oscillations may be related to the pathophysiology of bradykinesia. Event-related desynchronization (ERD) of these oscillations occur for 1–2 s preceding a voluntary movement in normal subjects and patients with PD treated with levodopa while only lasting around 0.5 s in untreated patients. Motor cortical rhythms were recorded from subdural strip electrodes in three patients with MSA-P while taking their regular dopaminergic medications. Following a ready cue, patients performed an externally cued wrist extension movement to a go cue. In addition, recordings were obtained during imagined wrist extension movements to the same cues and during self-paced wrist extensions. ERD and event-related synchronization were examined in subject-specific frequency bands. All patients showed movement-related ERD in subject-specific frequency bands below ~40 Hz in both externally cued and self-paced conditions. Preparatory ERD latency preceding self-cued movement was 900 ms in one patient and at or after movement onset in the other two patients. In the externally cued task, a short lasting (<1.3 s) ready cue-related ERD that was not sustained to movement onset was observed in two patients. Imagined movements resulted in go cue-related ERD with a smaller magnitude in the same two patients. These results indicate that the modulation of motor cortical oscillations in patients with MSA that are treated with levodopa is similar to that occurring in untreated patients with PD. The findings suggest that cortical activation in patients with MSA is diminished, may be related to pathophysiological changes occurring in the basal ganglia and correlates with the poor clinical response that these patients typically obtain with dopaminergic therapy. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
