1,6-二磷酸果糖治疗肺炎支原体感染心肌损害45例疗效观察

目的:探讨1,6-二磷酸果糖治疗肺炎支原体感染所致心肌损害的疗效。方法:MP-IgM阳性及MP-DNA阳性患儿90例,随机分为治疗组与对照组各45例,两组患儿均给予红霉素、营养心肌药物及对症治疗,治疗组在此基础上加用1,6-二磷酸果糖治疗。结果:两组患儿AST、LDH、CK、CK-MB、α-HBDH比较均有显著性差异(P<0.01)。肌钙蛋白I两组比较有显著差异(u=2.07,P<0.05)。心电图恢复正常例数两组患儿比较进行卡方检验有显著性差异(χ2=5.33,P<0.01)。结论:支原体感染心肌损害在应用有效抗生素及保护心肌药物治疗的同时,加用1,6-二磷酸果糖治疗,可明显提高疗效。

Clinical study of the effect of fructose-1, 6-diphosphate on 45 patients with myocardial injury caused by myoplasmal pneumonia

Objective: To explore the effect of fructose-1, 6-diphosphate (FDP) on myocardial injury resulting from mycoplasmal pneumoma (MP). Methods: Ninety patients with MP confirmed by positive MP-IgM and MP-DNA tests were randomized into two groups, the treatment one and the control one, each containing 45 patients. Besides the administration of erythromycin and symptomatic therapy to both groups, the treatment group were also given FDP, and then cardiac muscie enzymes together with cardiac troponin-I and ECG were tested. Results: Both the levels of the enzymes and those of the troponin were remarkably different between the two groups (the fomer P < 0.01, and the latter P < 0.05). The difference about the ECG recovery rates between the two groups was also significant (P < 0.01). Conclusion: During the treatment of myocardial injury from MP, the addition of FDP to the basic therapy of anti-inflammation and myocardial nutrients can markedly improve the treatment effect.