胰腺癌VEGF-C的表达与淋巴管生成的关系及意义

目的探讨血管内皮生长因子C(vascular endothelial growth factor C,VEGF-C)在胰腺癌淋巴管生成及其与淋巴结转移中的作用。方法采用免疫组织化学染色法,检测42例胰腺癌组织标本和10例正常胰腺组织标本的VEGF-C表达;应用酶组织化学方法检测癌周微淋巴管密度(microlymphatic vessel density,MLVD)。结果胰腺癌VEGF-C的阳性表达率为64．3％,显著高于正常对照组的20％(P<0．05);胰腺癌MLVD为21．93±6．39,显著高于正常对照组的4．40±2．07(P<0．001),VEGF-C表达与肿瘤组织MLVD及淋巴结转移呈正相关(P<0．05)。结论VEGF-C在胰腺癌淋巴管生成及其淋巴结转移中具有重要作用。

Relationship between the Expression of Vascular Endothelial Growth Factor C and Lymphangiogenesis in Human Pancreatic Cancer

Objective: To investigate the role the vascular endothelial growth factor C (VEGF-C) expression in lymphangiogenesis and lymph node metastasis in pancreatic cancer. Methods: The expression of VEGF-C in pancreatic cancer tissue of 42 cases and normal pancreatic tissue of 10 cases was detected by using immunohistochemical S-P method. The microlymphatic vessel density (MLVD) of both tissues was measured by enzyme-histochemical method at the same time. Results: The VEGF-C positive expression rate was significantly higher in pancreatic cancer tissue (64.3%) than in normal pancreatic tissue (20%, P<0.05). The MLVD was significantly higher in pancreatic cancer tissue (21.93±6.39) than that in normal pancreatic tissue (4.40±2.07, P<0.001). The VEGF-C positive expression rate, MLVD and lymph node metastasis had a positive correlation. Conclusion: The VEGF-C may play an important role in the lymphangiogenesis and lymph node metastasis of pancreatic cancer.