Glycine-evoked release of [3H]acetylcholine from rat striatal slices is independent of the NMDA receptor |
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Authors: | Cynthia A. Taylor Cindy Tsai John Lehmann |
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Affiliation: | (1) Ciba-Geigy Corp., Neuroscience Research, Pharmaceuticals Division, 07901 Summit, NJ, USA;(2) Anaquest, BOC Health Care 100 Mountain Ave., 07974 Murray Hill, NJ, USA |
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Abstract: | Summary KCl-, NMDA-, and glycine-evoked release of [3H]acetylcholine was studied in superfused rat striatal slices. KCl-evoked release of [3H]acetylcholine was inhibited by 1.2 mM MgC12 and 100 M lidocaine. Similarly, NMDA-evoked release was inhibited by MgCl2 and lidocaine as well as 10 M CGS 19755, a competitive antagonist at NMDA receptors, and 10 nM MK-801, a noncompetitive antagonist of NMDA-induced responses. Glycine-evoked release was calcium-dependent and was inhibited by 0.1 M strychnine whereas KCl- and NMDA-evoked release were resistant to strychnine. In addition, lidocaine inhibited the glycine-induced response. Cross-tachyphylaxis was not observed between NMDA- and glycine-evoked release. These results indicate that the strychnine-sensitive, glycine-evoked release of [3H]acetylcholine is independent of the NMDA receptor. |
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Keywords: | Glycine NMDA [3H]Acetylcholine release Rat striatal slices |
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