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Optimal Design for Model Discrimination and Parameter Estimation for Itraconazole Population Pharmacokinetics in Cystic Fibrosis Patients |
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| Authors: | Timothy H. Waterhouse Stefanie Redmann Stephen B. Duffull John A. Eccleston |
| Affiliation: | (1) School of Physical Sciences, The University of Queensland, Brisbane, Australia;(2) School of Pharmacy, The University of Queensland, Brisbane, Australia;(3) Department of Mathematics, The University of Queensland, Brisbane, QLD 4072, Australia |
| Abstract: | Optimal sampling times are found for a study in which one of the primary purposes is to develop a model of the pharmacokinetics of itraconazole in patients with cystic fibrosis for both capsule and solution doses. The optimal design is expected to produce reliable estimates of population parameters for two different structural PK models. Data collected at these sampling times are also expected to provide the researchers with sufficient information to reasonably discriminate between the two competing structural models |
| Keywords: | itraconazole optimal design model discrimination pharmacokinetic modelling population approach |
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