组织型纤溶酶原激活物-抑制剂复合物在冠心病病人中表达变化及与预后相关性分析

目的研究组织型纤溶酶原激活物-抑制剂复合物（t-PAIC）在冠心病病人中表达变化及与预后的相关性。方法选择180例冠心病病人作为冠心病组，其中不稳定心绞痛107例，稳定心绞痛73例；择同期非冠心60例为对照组。观察冠心病组与对照组血清肌酸激酶同工酶（CKMB）、总胆固醇（TC）、C反应蛋白（CRP）以及空腹血糖（FBG）水平以及纤溶酶原激活物抑制剂1（PAI-1）与组织纤维溶酶原激活物（t-PA）水平，并分析冠心病组病人三支病变、双支病变及单支病变与对照组病人的PAI-1、t-PA水平变化。结果不稳定性心绞痛组血清TC、CRP、FBG、CKMB、PAI-1水平均高于稳定性心绞痛组与对照组，t-PA水平均低于稳定性心绞痛组与对照组（P < 0.05~P < 0.01）；稳定性心绞痛组病人血清CRP、FBG、CKMB、PAI-1水平高于对照组，差异均有统计学意义（P < 0.05~P < 0.01）。血清PAI-1水平在三支病变组、双支病变组、单支病变组及对照组中依次降低，血清t-PA水平则依次升高，差异均有统计学意义（P < 0.01）。结论t-PAIC与冠心病严重程度、冠状动脉狭窄数存在相关性，且病情越严重、冠状动脉狭窄数越多则PAI-1水平越高，t-PA水平越低，临床可通过检测t-PAIC水平预测冠心病病人病情发展情况。

Study on the expression levels of tissue plasminogen activator-inhibitor complex in patients with coronary heart disease and its correlation with prognosis

ObjectiveTo investigate the expression level change of tissue plasminogen activator-inhibitor complex(t-PAIC) in patients with coronary heart disease(CHD), and its correlation with prognosis.MethodsOne hundeed and eighty patients with CHD, which included 107 cases with unstable angina pectoris and 73 cases with stable angina pectoris, were set as the CHD group, and 60 patients without CHD were as the control group.The serum levels of creatine kinase isoenzyme(CKMB), total cholesterol(TC), C reactive protein(CRP), fasting blood glucose(FBG), plasminogen activator inhibitor 1(PAI-1) and tissue plasminogen activators(t-PA) were observed in two groups.The three, double and single-vessel lesions in CHD group, and levels change of PAI-1 and t-PA in control group were analyzed.ResultsThe serum levels of TC, CRP, FBG, CKMB and PAI-1 in unstable angina pectoris patients of CHD group were significantly higher than those in stable angina pectoris pateints of CHD group and control group(P < 0.05), and the serum level of t-PA in unstable angina pectoris of CHD group was lower than that in stable angina pectoris pateints of CHD group and control group(P < 0.05 to P < 0.01).The serum levels of TC, CRP, FBG, CKMB and PAI-1 in stable angina pectoris patients of CHD group were higher than those in control group(P < 0.05 to P < 0.01).The serum levels of PAI-1 and t-PA in the three-vessel lesion group, double-vessel lesion group, single-vessel lesion group and control group decreased in turn, respectively, and the differences of which were statistically significant(P < 0.01).ConclusionsThe t-PA level is correlated with the severity of CHA and number of coronary artery stenosis.The more severe the disease and more coronary stenosis are, the higher the level of PAI-1 and lower the level of t-PA are.The disease development of patients with CHD can be predicted through the detection of t-PA.