阻塞性睡眠呼吸暂停综合征并功能性便秘的相关性研究

目的对阻塞性睡眠呼吸暂停综合征（OSAS）并功能性便秘（FC）的相关性进行分析研究。方法选取OSAS病人185例作为研究对象，按照是否合并FC分为观察组（n=82）和对照组（n=103）。统计并比较2组病人的睡眠呼吸暂停低通气指数（AHI）、睡眠参数、睡眠结构和体质量指数（BMI）。结果观察组AHI、BMI值均显著高于对照组（56.9±17.34）vs（32.3±11.09）（P < 0.01）。中重度FC+OSAS组病人的AD均较对照组显著增高（P < 0.01），minSaO₂%则较对照组显著降低（P < 0.01）。中度FC+OSAS组病人睡眠1+2期比例、呼吸相关微觉醒指数分别为（79.6±11.7）（30.1±10.4），均显著高于对照组（P < 0.01）。重度FC+OSAS组病人睡眠1+2期比例、呼吸相关微觉醒指数分别为（82.3±6.7）（35.3±17.6），均显著高于对照组（P < 0.01）。中度FC+OSAS组病人慢波睡眠比例、睡眠REM期比例值分别为（8.2±7.3）（9.6±2.5），重度FC+OSAS组病人慢波睡眠比例、睡眠REM期比例值分别为（6.1±5.2）（8.7±1.8），均显著低于对照组（P < 0.01）。结论FC和OSAS密切相关。

Study on the correlation of obstructive sleep apnea syndrome with functional constipation

ObjectiveTo investigate the correlation between obstructive sleep apnea syndrome(OSAS) and functional constipation(FC).MethodsOne hundred and eighty-five patients with OSAS were divided into the observation group(82 OSAS cases complicated with FC) and control group(103 cases).The apnea-hypopnea index(AHI), sleep parameters, sleep structure and body mass index(BMI) were comapred between two groups.ResultsThe AHI and BMI values in observation group were significantly higher than those in control group(56.9±17.34) vs(32.3±11.09)](P < 0.01).The AD in moderate and severe FC+OSAS group was significantly higher than that in control group (P < 0.01), while minSaO₂% was significantly lower than that in control group (P < 0.01).In the moderate(FC+OSAS) group, the proportion of sleep stage 1+2 and respiration-related microarousal index were(79.6±11.7) and (30.1±10.4), respectively, which were significantly higher than those in control group(P < 0.01).In the severe(FC+OSAS) group, the proportion of sleep stage 1+2 and respiration related microarousal index were(82.3±6.7) and (35.3±17.6), respectively, which were significantly higher than those in control group(P < 0.01).The proportions of slow-wave sleep and REM sleep in the moderate and severe (FC+OSAS) groups were(8.2±7.3) and(9.6±2.5)] and(6.1±5.2) and(8.7±1.8)], respectively, and which were significantly lower than those in control group(P < 0.01).ConclusionsFC is closely related to OSAS.