关节镜清理术联合透明质酸钠对膝骨关节炎病人关节液细胞间黏附分子-1、白细胞介素-6的影响

目的观察关节镜清理术联合透明质酸钠对膝骨关节炎病人关节液中细胞间黏附分子-1（ICAM-1）、白细胞介素（IL）-6含量的影响，以及治疗后的并发症情况。方法选取膝骨关节炎病人106例，并将其随机分为对照组和观察组，每组53例。对照组病人的治疗方案为关节清理术，观察组病人的治疗方案为关节清理术联合透明质酸钠。观察两种不同治疗方案对膝骨关节炎病人关节液ICAM-1、IL-6含量的影响，以及病人治疗后并发症的情况。结果治疗前, 2组病人关节液内ICAM-1和IL-6的含量差异无统计学意义（P>0.05）；治疗后，2组关节液内ICAM-1、IL-6的含量均显著降低（P < 0.01），且观察组病人关节液内ICAM-1和IL-6的含量低于对照组（P < 0.05和P < 0.01）。治疗后观察组有3例病人出现关节内血肿，对照组5例；观察组有4例病人出现关节胀痛，对照组7例，2组差异均无统计学意义（P>0.05）；观察组2例病人出现关节活动障碍，对照组8例，差异有统计学意义（P < 0.05）。结论关节镜清理术联合透明质酸钠治疗膝骨关节炎可以显著提高临床效果，降低病人关节液ICAM-1、IL-6含量，改善预后。

Effect of arthroscopic debridement combined with sodium hyaluronate on the levels of ICAM-1 and IL-6 in synovial fluid of patients with knee osteoarthritis

ObjectiveTo observe the effects of arthroscopic debridement combined with sodium hyaluronate on the levels of intercellular adhesion molecule(ICAM)-1 and interleukin(IL-6)in synovial fluid and complications after treatment in patients with knee osteoarthritis.MethodsA total of 106 patients with knee osteoarthritis were randomly divided into the control group and observation group(53 cases in each group).The control group was treated with joint debridement, and the observation group was treated with joint debridement combined with sodium hyaluronate.The levels of ICAM-1 and IL-6 in synovial fluid, and complications after treatment in two groups were observed.ResultsBefore treatment, the differences of the levels of ICAM-1 and IL-6 in synovial fluid were not statistically significance between two groups(P>0.05).After treatment, the levels of ICAM-1 and IL-6 in synovial fluid in two groups significantly decreased, and the levels of ICAM-1 and IL-6 in observation group were significantly lower than those in control group(P < 0.05 and P < 0.01).Three cases with hematoma in observation group and 5 cases with hematoma in control group were found.Four cases with joint pain in observation group and 7 cases with joint pain in control group were found, and the difference of which was not statistically significant(P>0.05).Two cases with joint mobility disorder in observation group and 8 cases with joint mobility disorder in control group were found, and the difference of which was statistically significant(P < 0.05).ConclusionsArthroscopic debridement combined with sodium hyaluronate in the treatment of knee osteoarthritis can significantly improve the clinical effect, reduce the content of ICAM-1 and IL-6 in synovial fluid, and improve the prognosis of patients.