降钙素原、C-反应蛋白与妊娠晚期B族链球菌感染状态的关系

目的 探讨血清降钙素原(procalcitonin,PCT)、C-反应蛋白(C-reactive protein,CRP)水平在妊娠晚期B族链球菌(group B streptococcus,GBS)阳性孕妇感染状态中的判断价值.方法 选取2018年4月至2019年12月在华北理工大学附属医院分娩的妊娠晚期GBS阳性孕...

The relationship between procalcitonin,C-reactive protein and group B streptococcal infection in late pregnancy

Objective To investigate the value of serum procalcitonin(PCT)and C-reactive protein(CRP)levels in the infection status of group B streptococcus(GBS)positive pregnant women in late pregnancy.Methods 190 cases of GBS positive pregnant women who gave birth in Affiliated Hospital of North China University of Technology from April 2018 to December 2019 were included in the study,including 46 cases of GBS carrier(GBS carrier group)and 120 cases of GBS subclinical infection(GBS sub-infection group),24 cases of chorioamnionitis(GBS amnionitis group);20 cases of normal late pregnancy pregnant women who gave birth in our hospital during the same period were selected as the normal group.After the study subjects gave birth,the maternal cubital venous blood was taken,and the serum CRP and PCT levels were detected by electrochemiluminescence method,and the changes in the serum CRP and PCT levels of each group of pregnant women were analyzed.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of CRP and PCT on the infection status of GBS positive pregnant women in late pregnancy.Results The serum CRP levels of pregnant women in the GBS carrier group increased,and the difference was statistically significant(P<0.05),and there was no significant difference in PCT;the serum PCT and CRP of pregnant women in the GBS sub-infection group and the GBS amnitis group increased,and the differences were statistically significant(P<0.05).Compared with the serum PCT and CRP of pregnant women in the GBS amnionitis group,the serum PCT and CRP of pregnant women in the GBS carrier group and the GBS sub-infected group were lower,and the differences were statistically significant(P<0.05).Compared with the serum PCT and CRP of pregnant women in the GBS sub-infected group,the serum PCT and CRP of pregnant women in the GBS carrier group decreased,and the differences were statistically significant(P<0.05).The AUC of PCT detection in the serum of GBS-positive pregnant women were 0.165,0.632,0.988,respectively,and the AUC of CRP detection in the serum were 0.168,0.687,0.934,respectively.Among them,serum PCT and CRP had the highest diagnostic efficiency in GBS amnionitis;GBS sub-infection was the second;The diagnostic efficiency of GBS carrier is relatively low.Conclusion The levels of PCT and CRP in the serum of GBS-infected pregnant women in the third trimester of pregnancy have certain value in predicting GBS amnionitis,and they can be used as early diagnostic indicators of the infection status of GBS-positive pregnant women.