加贝酯联合生长抑素与奥美拉唑静脉滴注治疗老年重症胰腺炎患者的效果分析

目的 分析加贝酯联合生长抑素与奥美拉唑静脉滴注治疗老年重症胰腺炎患者的效果.方法 前瞻性选择2017年5月～2019年5月海南省干部疗养院收治的120例老年重症胰腺炎患者,应用双色球法随机分为常规组和联合组,各60例.两组患者均给予抗感染、维持水和电解质平衡、止痛、胃肠减压、减少胰液及胃液的分泌等基础方式进行治疗,常规...

Effect of gabexate combined with somatostatin and omeprazole on proinflammatory cytokines in elderly patients with severe pancreatitis

Objective To analyze the effect of gabeate combined with somatostatin and omeprazole intravenous infusion in the treatment of elderly patients with severe pancreatitis. Methods a total of 120 elderly patients with severe pancreatitis from May 2017 to may 2019 were randomly divided into two groups:conventional group and combined group.Two groups of patients were given anti infection,maintaining water and electrolyte balance,pain relief,gastrointestinal decompression,reducing the secretion of pancreatic juice and gastric juice and other basic treatment,conventional group was treated with somatostatin and omeprazole intravenous drip,combined group was treated with gabexate on the basis of conventional treatment.The clinical efficacy,improvement of clinical symptoms and adverse reactions,intestinal mucosal barrier function,gastrointestinal hormone and proinflammatory cytokines levels before and after treatment were compared and analyzed between the two groups. Results the total effective rate of the combined group was 98.33%,which was significantly higher than that of the conventional group(80.00%)(P < 0.05).The relief time of abdominal pain,abdominal distension,amylase recovery time and hospital stay time of patients in the combined group were significantly shorter than those in the conventional group. The anal exhaust rate within 24 h after admission was significantly higher than that of the conventional group,and the intra-abdominal hypertension was significantly lower than that of the conventional group,with statistically significant differences(P < 0.05).After treatment,the levels of D-lactate,DAO,GAS,TNF-α,IL-8 and CRP in the combined group were significantly lower than those in the conventional group,and the levels of MTL were significantly higher than those in the conventional group(P < 0.05).There were no adverse reactions in the two groups. Conclusion The efficacy of gabeate combined with somatostatin and omeprazole intravenous infusion in the treatment of elderly patients with severe pancreatitis is significant,which significantly improves the clinical symptoms of the patients,reduces the level of proinflammatory cytokines,improves the intestinal mucosal barrier function and gastrointestinal hormones,and is relatively safe.