心血管病变对多囊卵巢综合征育龄妇女糖脂代谢、胰岛素抵抗及性激素的影响

目的探讨心血管病变对多囊卵巢综合征（PCOS）育龄妇女糖脂代谢、胰岛素抵抗及性激素的影响。方法选取80例PCOS病人为研究对象，均行血糖、胰岛素、血脂、性激素水平检查。根据是否合并心血管病变分为合并心血管病变组（n=17）和未合并心血管病变组（n=63），比较上述检查指标水平，并比较2组糖代谢异常、血脂异常、胰岛素抵抗（IR）、高雄激素血症（HA）发生率。结果合并心血管病变组较未合并心血管病变组餐后2 h血糖、空腹胰岛素、餐后2 h胰岛素、稳态模型胰岛素抵抗指数、总胆固醇、三酰甘油、低密度脂蛋白、睾酮、性激素结合蛋白水平均明显升高（P < 0.05~P < 0.01）。合并心血管疾病组糖代谢异常、IR、HA发生率均明显高于未合并心血管病变组（P < 0.05）。结论合并心血管病变的PCOS病人发生糖脂代谢异常、IR及HA的风险更大。

Effect of cardiovascular disease on glucose and lipid metabolism,insulin resistance and sex hormone in fertile women with polycystic ovarian syndrome

ObjectiveTo investigate the effects of cardiovascular disease on the glucose and lipid metabolism, insulin resistance and sex hormones in fertile women with polycystic ovarian syndrome(PCOS).MethodsThe levels of the blood glucose, insulin, blood lipid and sex hormone in 80 patients with PCOS were detected, and the patients were divided into the cardiovascular disease group(n=17)and non-cardiovascular disease group(n=63)according to the occurrence of cardiovascular disease.The levels of above-mentioned indexes, and incidence rates of abnormal glucose metabolism, dyslipidemia, insulin resistance(IR)and hyperandrogenism(HA)were compared between two groups.ResultsThe levels of postprandial 2 h blood glucose, fasting insulin, postprandial 2 h insulin, steady-state model insulin resistance index, total cholesterol, triacylglycerol, low-density lipoprotein, testosterone and sex hormone binding globulin in cardiovascular disease group were significantly higher than those in non-cardiovascular disease group(P < 0.05 to P < 0.01).The incidence rates of abnormal glucose metabolism, dyslipidemia, IR and HA in cardiovascular disease group were significantly higher than those in non-cardiovascular disease group(P < 0.05).ConclusionsThe risks of abnormal glucose and lipid metabolism, IR and HA are relatively higher in PCOS patients complicated with cardiovascular disease.