老年腔隙性脑梗死病人尿液AD7c-NTP及血清C反应蛋白与血管性轻度认知功能障碍的相关性

目的分析老年腔隙性脑梗死病人尿液阿尔茨海默病相关的神经丝蛋白(AD7c-NTP)及C反应蛋白(CRP)与血管性轻度认知功能障碍的相关性。方法选取268例老年腔隙性脑梗死病人作为研究对象。其中有血管性轻度认知功能障碍病人117例，为观察组，其余151例为对照组。观察并记录2组病人人口学特征、既往病史、AD7c-NTP及CRP等生化指标数据、蒙特利尔认知评估量表(MoCA)评分，剑桥老年认知检查表-中国修订版(CAMCOG-C)评分、简易精神状态评价量表(MMSE)评分等临床资料，并进行统计分析。结果观察组男性病人占比、糖尿病史占比、三酰甘油、AD7c-NTP及CRP水平均高于对照组(P < 0.05~P < 0.01)，观察组病人MoCA评分、CAMCOG-C评分及MMSE评分均低于对照组(P < 0.05)；多因素logistic回归分析显示，糖尿病史、AD7c-NTP及CRP水平升高均是老年腔隙性脑梗死病人认知功能受损的危险因素(P < 0.05~P < 0.01)；相关性分析显示，AD7c-NTP及CRP浓度与MoCA评分均呈显著负相关(r=-0.717、-0.656，P < 0.01)。结论AD7c-NTP及CRP水平与老年腔隙性脑梗死病人认知功能受损程度呈正相关，早期监测AD7c-NTP、CRP指标有助于预测血管性轻度认知功能障碍，以做到早诊断、早治疗。

Correlation between the levels of urinary AD7 C-NTP and serum C-reactive protein and vascular mild cognitive dysfunction in elderly patients with lacunar cerebral infarction

ObjectiveTo analyze the correlation between the levels of urinary Alzheimer's disease-related neurofilament protein(AD7C NTP) and serum C-reactive protein(CRP), and vascular mild cognitive impairment in elderly patients with lacunar cerebral infarction.MethodsTwo hundred and sixty-eight elderly patients with lacunar cerebral infarction were selected as the research objects.Among them, 117 patients with vascular mild cognitive impairment and other 151 patients were divided into the observation group and control group, respectively.The demographic characteristics, past medical history, AD7C NTP, CRP and other biochemical indicators were recorded, and the scores of Montreal Cognitive Assessment Scale(MoCA), CAMCOG-C and MMSE, and other clinical data in two groups were analyzed.ResultsThe proportion of male patients, proportion of diabetes history, and the concentrations of triglyceride, AD7C-NTP and CRP in observation group were higher than those in control group(P < 0.05 to P < 0.01).The MOCA score, CaMCOG-C score and MMSE score in observation group were lower than those in control group(P < 0.05).The results of multivariate logistic regression analysis showed that diabetes history, levels of AD7C-NTP and CRP increasing were the risk factors of cognitive impairment in elderly patients with lacunar cerebral infarction(P < 0.05 to P < 0.01).The results of correlation analysis showed that the levels of AD7C-NTP and CRP were significantly negatively correlated with MOCA score(r=-0.717, -0.656, P < 0.01).ConclusionsThe levels of AD7c-NTP and CRP are positively correlated with cognitive impairment in elderly patients with lacunar infarction.Early monitoring of AD7c-NTP and CRP indicators can help predict the vascular mild cognitive dysfunction, so as to achieve early diagnosis and early treatment.