玻璃酸钠联合重组人表皮生长因子治疗老年性白内障术后干眼症的临床疗效分析

目的探讨玻璃酸钠联合重组人表皮生长因子(rhEGF)治疗老年性白内障术后干眼症的临床效果。方法将行白内障超声乳化术后确诊为干眼症的90例病人，随机分为观察组和对照组，每组45例。对照组在抗炎药物基础上，给予玻璃酸钠滴眼液，1滴/次，3次/天。观察组在对照组治疗的基础上给予rhEGF滴眼液，1滴/次，3次/天。2组治疗时间均为28 d。比较2组治疗效果，分别于治疗前、治疗14 d、治疗28 d时进行泪膜破裂时间(BUT)检测、基础泪液分泌试验(SITI)、角膜荧光素染色(FL)、症状评分，检测泪液白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平。结果伴随治疗时间的进展，2组BUT和SIT值均明显升高(P < 0.05)，FL、症状评分、IL-6、hs-CRP明显降低(P < 0.05)。观察组治疗14 d、28 d的BUT、SIT值均明显高于对照组(P < 0.01)；观察组治疗14 d、28 d的FL值、症状评分、IL-6、hs-CRP均明显低于对照组(P < 0.01)。结论玻璃酸钠与rhEGF联合治疗老年白内障术后干眼症疗效显著。

Clinical effect analysis of sodium hyaluronate combined with recombinant human epidermal growth factor in the treatment of xerophthalmia after senile cataract surgery

ObjectiveTo observe the clinical effects of sodium hyaluronate combined with recombinant human epidermal growth factor(rhEGF) in the treatment of xerophthalmia after senile cataract surgery.MethodsNinety xerophthalmia patients after phacoemulsification were randomly divided into the observation group and control group(45 cases in each group).The control group was treated with sodium hyaluronate eye drops on the basis of anti-inflammatory drugs, 1 drop/time, 3 times/day.The observation group was additionally treated with eye drops, 1 drop/time, 3 times/day based on the control group.The treatment time in two groups was 28 days.The tear film break-up time(BUT) test, Schirmer I test(SITI), corneal fluorescent staining(FL) and symptom score in two groups were performed before treatment, after 14 and 28 days of treatment.The levels of interleukin-6(IL-6) and hypersensitive C reactive protein(hs-CRP) in tears of two groups were detected.ResultsWith the progress of treatment time, the BUT and SIT values in two groups significantly increased(P < 0.05), and the FL, symptom score, levels of IL-6 and hs-CRP significantly decreased(P < 0.05).The BUT and SIT values in observation group after 14 days and 28 days of treatment were significantly higher than those in control group(P < 0.01).The FL value, symptom score, levels of IL-6 and hsCRP in observation group after 14 and 28 days of treatment were significantly lower than those in control group(P < 0.01).ConclusionsThe combination of sodium hyaluronate and rhEGF in the treatment of xerophthalmia after senile cataract surgery is effective.