| 亚硝酸钴钠肌注的抗氰效果 |
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| 引用本文： | 毛坚耀,王宇,齐来法. 亚硝酸钴钠肌注的抗氰效果[J]. 第二军医大学学报, 1987, 0(3) |
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| 作者姓名： | 毛坚耀 王宇 齐来法 |
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| 作者单位： | 第二军医大学医学防护教研室(毛坚耀，王宇)，北京军区军医学校(齐来法) |
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| 摘 要： | 本文报道了狗氰化钾1～2.5LD肌肉注射中毒后5～10min待出现惊厥时,或氢氰酸2LD_(50)吸入中毒后15s,用亚硝酸钴钠(10％)二甲亚砜溶液肌肉注射,动物活存率分别为20/22及8/10。猫致死量氢氰酸吸入中毒出现惊厥时,用该药肌肉注射亦取得良好的治疗效果。本研究为寻找抗毒作用快,给药途径方便适合于现场抢救用抗氰药提供实验依据。
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| 关 键 词： | 亚硝酸钴钠 氰化物中毒 二甲亚砜 |
THE ANTAGONISTIC EFFECT OF SODIUM COBALTINITRITE BY INTRAMUSCULAR INJECTION ON CYANIDE INTOXICATION |
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| Mao Jianyao,et al. THE ANTAGONISTIC EFFECT OF SODIUM COBALTINITRITE BY INTRAMUSCULAR INJECTION ON CYANIDE INTOXICATION[J]. Former Academic Journal of Second Military Medical University, 1987, 0(3) |
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| Authors: | Mao Jianyao et al |
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| Affiliation: | Department of Protective Medicine |
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| Abstract: | This paper reports the antagonistic effect of sodium cobaltinitrite by intramus-cular injection on cyanide intoxication. The sodium cobaltinitrite (10%) dime-thylsulfoxide solution was administrated intramuscularly when convulsion appeared in dogs 5-10 min after intramuscular injection of potassium cyanide(1-2.5LD) or 15s after inhalation of hydrocyanic acid (2LD50). The animal survival rate was 20/22 and 8/10, respectively. The cats intoxicated by lethal dose of hydrocyanic acidinhalation were given sodium cobaltinitrite intramuscularly, and a good therapeutic effect was also obtained.This study provides an experiment basis in search of an antagonist of cyanide, which takes effect rapidly, is administrated conveniently and is suitable rescue in the field, with a convenient administrating means. |
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| Keywords: | sodium cobaltinitrite cyanide poisoning dimethyl sulfoxide |
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