| 强化大豆高支链氨基酸混合物Ⅰ、治疗实验性肝性脑病的研究 |
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| 引用本文： | 郭俊生,赵法伋,陈洪章,杨孝达,罗勇庆,卢善刚,姚依敏,张振球,陆翔英,陈翠芬,谢保源.强化大豆高支链氨基酸混合物Ⅰ、治疗实验性肝性脑病的研究[J].第二军医大学学报,1985(6). |
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| 作者姓名： | 郭俊生 赵法伋 陈洪章 杨孝达 罗勇庆 卢善刚 姚依敏 张振球 陆翔英 陈翠芬 谢保源 |
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| 作者单位： | 第二军医大学军队卫生教研室
(郭俊生，赵法伋，陈洪章)，上海粮食科学研究所
(杨孝达，罗勇庆，卢善刚，姚依敏，张振球，陆翔英，陈翠芬)，上海市医药工业研究院(谢保源) |
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| 摘 要： | 强化大豆高支链氨基酸混合物(Ⅰ)是采用特殊工艺水解大豆蛋白后,添加少量个别氨基酸组成。其氨基酸组成的特点是,支链氨基酸含量高,芳香族氨基酸含量低,氨基酸模式类似HEP-Ⅱ肝病氨基酸组成。动物实验表明,该种氨基酸混合物能改善D-氨基半乳糖致大鼠肝性脑病症状,使血清支/芳比正常化,减少动物死亡数等。这些结果提示,强化大豆高支链氨基酸混合物(Ⅰ)对肝性脑病有较好的治疗作用。
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| 关 键 词： | 大豆 氨基酸 肝性脑病 疾病模型 动物 大鼠 |
STUDIES ON THE TREATMENT OF EXPERIMENTAL HEPATIC ENCEPHALOPATHY WITH ENRICHED SOYBEAN HIGH BRANCHED-CHAIN AMINO ACID MIXTURE(I) |
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| Guo Junsheng,et al..STUDIES ON THE TREATMENT OF EXPERIMENTAL HEPATIC ENCEPHALOPATHY WITH ENRICHED SOYBEAN HIGH BRANCHED-CHAIN AMINO ACID MIXTURE(I)[J].Academic Journal of Second Military Medical University,1985(6). |
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| Authors: | Guo Junsheng |
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| Institution: | Department of Military Hygiene |
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| Abstract: | The enriched soybean high branched-chain amino acid mixture(I) was composed of soybean protein hydrolyzed by special method with a few typies additional amino acids in small amounts.The mixture(I)containd high amounts of branched-chain amino acids and low of aromatic amino acids. Its amino acid pattern was similar to that of HEP-II.The animal experiments showed that the mixture(I) could improve hepatic encephalopathy induced by D-galactosamine in rats,and normalize the serum ration of leu-cine, isoleucine and valine to phenylalamine and tyrosine, and increase survival of rats. These results suggested that the mixture(I) has a better curative effect on hepatic encephalopathy. |
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| Keywords: | soybean amino acid hepatic encephalopathy disease models animal rats |
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