电针对大鼠大脑皮层SI区神经元伤害感受性反应的影响

<正> 大脑皮层是否参与疼痛的感受长期以来是一个争议的问题,但近年来记录皮层发诱电位和单个神经元活动的方法已证明伤害感受性信息可以达到皮层体感区(SⅠ

Effect of electro-acupuncture on the nociceptive responses of SI cortical neurons in the rat]

1. The effect of electro-acupuncture (EA) on the responses of single SI cortical nociceptive neurons to peripheral natural stimuli were observed in unanesthetized and paralyzed rats. 2. After EA, the responses to noxious mechanical and/or thermal stimulation reduced markedly in 14 (70%) out of 20 neurons tested, and slightly increased or unchanged in the remaining 6 neurons, as compared to the responses before EA. 3. In contrast to the variation of nociceptive responses, the responses to innocuous mechanical stimulation increased in 9 neurons and unchanged in other 9 neurons, while deceased in only 2 neurons. 4. A small portion of the neurons were activated by EA stimulation, while their responses to noxious stimulation were inhibited. 5. It is considered that the selective inhibition of the nociceptive responses of SI cortical neurons might be a part of the mechanisms of acupuncture analgesia.