| 再生障碍性贫血发病机制的研究进展 |
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| 引用本文： | 王方,金润铭. 再生障碍性贫血发病机制的研究进展[J]. 国际儿科学杂志, 2010, 37(2). DOI: 10.3760/cma.j.issn.1673-4408.2010.02.007 |
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| 作者姓名： | 王方 金润铭 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院儿科,武汉,430022;华中科技大学同济医学院附属协和医院儿科,武汉,430022 |
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| 摘 要： | 再生障碍性贫血是一种获得性骨髓造血功能衰竭综合征.主要表现为骨髓造血功能低下、全血细胞减少以及贫血、出血、感染综合征.其发病机制尚未完全明确,主要涉及造血干/祖细胞缺陷、免疫功能紊乱、骨髓造血微环境异常三个方面.近年来各国学者对再生障碍性贫血进行了大量的临床以及实验研究,对其发病机制有了更进一步的认识,该文对此方面的研究进展做简要综述.
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| 关 键 词： | 贫血 再生障碍性 全血细胞减少 造血干细胞 免疫紊乱 |
Progress of pathogenesis of aplastic anemia |
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| WANG Fang,JIN Run-ming. Progress of pathogenesis of aplastic anemia[J]. International Journal of Pediatrics, 2010, 37(2). DOI: 10.3760/cma.j.issn.1673-4408.2010.02.007 |
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| Authors: | WANG Fang JIN Run-ming |
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| Abstract: | Aplastic anemia is an acquired bone marrow failure syndrome,characterized by an empty bone marrow,pancytopenia,as well as anemia,bleeding,infection syndrome.The pathogenesis of aplastic anemia has not yet been completely clear.Some of the proposed causes include hematopoietic stem/ progenitor cell deficiency,immune disorders,and abnormalities in the hematopoietic microenvironment.In recent years,further clinical and experimental studies have accumulated to recognize the pathogenesis of aplastic anemia. |
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| Keywords: | Aplastic anemia Pancytopenia Hematopoietic stem cells Immune disorders |
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