Normal fertilization in men with high antibody sperm binding by the addition of sufficient unbound sperm in vitro |
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| Authors: | F. Hamilton A. L. Gutlay-Yeo D. R. Meldrum |
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| Affiliation: | (1) AMI South Bay Hospital in Vitro Fertilization Center, 514 North Prospect Avenue, 90277 Redondo Beach, California;(2) University of California Los Angeles (UCLA) School of Medicine, 514 North Prospect Avenue, 90024 Los Angeles, California |
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| Abstract: | A high incidence of fertilization failure has been reported in men with over 70% of their sperm bound with isoantibodies. In three men with greater than 80% antisperm antibody binding with IgG and IgA immunolobulins, a normal rate of fertilization (29/46 oocytes; 60%) was achieved by adding a sufficient number of motile sperm to provide at least 50,000 unbound sperm per oocyte. This method appears to be simple and more effective than attempting to separate unbound sperm in vitro. |
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| Keywords: | antisperm antibodies fertilization |
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