| 羟自由基（OH·）对人胚肺成纤维细胞的体外作用 |
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| 引用本文： | 张尚明,罗玲,郭平,户万秘,王秋菊,曹兆丰.羟自由基（OH·）对人胚肺成纤维细胞的体外作用[J].卫生研究,1994(4). |
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| 作者姓名： | 张尚明 罗玲 郭平 户万秘 王秋菊 曹兆丰 |
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| 作者单位： | 华北煤炭医学院免疫病理研究室 |
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| 摘 要： | 观察了由Ｆｅｎｔｏｎ反应产生的羟自由基（ＯＨ·）对人胚肺成纤维细胞的体外作用。结果表明，ＯＨ·能明显促进成纤维细胞增殖和胶原合成。由此推测，ＯＨ·可能对矽肺的发生起到一定作用。这个结论为矽肺的抗氧化防治提供了进一步理论依据。
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| 关 键 词： | 羟自由基，脂质过氧化，成纤维细胞，石英，矽肺 |
Effect of exogenous hydroxyl radicals on human embryo-lung fibroblasts in vitro |
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| Zhang Shangming, Luo Ling, Guo Ping.Effect of exogenous hydroxyl radicals on human embryo-lung fibroblasts in vitro[J].Journal of Hygiene Research,1994(4). |
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| Authors: | Zhang Shangming Luo Ling Guo Ping |
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| Abstract: | The result indicated that hydroxyl radicals could enhance uptake of 3H-TdR and 3 H-Proline, proliferation and collagen synthesis of cultured HELF. Therefore, hydroxyl radicals may play a role in silicosis. The results indicate the possibility of prevention and therapy of silicosis by antioxidant and also help us to understand other fibrosis diseases. |
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| Keywords: | Hydroxyl radical lipid peroxidation fibroblast silicosis |
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