| 影响小鼠视网膜检查的突发性可逆性晶状体混浊 |
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| 引用本文： | 李才锐,孙曙光,Ireni Ali Rahman,Chooi May Lai. 影响小鼠视网膜检查的突发性可逆性晶状体混浊[J]. 国际眼科杂志, 2010, 10(1): 21-22. DOI: 10.3969/j.issn.1672-5123.2010.01.007 |
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| 作者姓名： | 李才锐 孙曙光 Ireni Ali Rahman Chooi May Lai |
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| 作者单位： | 671000,中国云南省大理市,云南大理学院附属医院眼科;澳大利亚狮子眼科研究所分子眼科中心;云南大理学院附属医院眼科,中国云南省大理市,671000;澳大利亚狮子眼科研究所分子眼科中心;西澳大学眼科和视光学中心 |
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| 摘 要： | 目的:评价氯胺酮/甲苯噻嗪麻醉对小鼠晶状体的影响。方法:用氯胺酮(60mg/kg)/甲苯噻嗪(10mg/kg)腹腔注射,分别麻醉4,8,12和16wk的Kimba小鼠(n=10)和野鼠(n=8)。托吡卡胺眼液(25g/L)扩大瞳孔后用HRA+OCT检查晶状体状态和视网膜病变。结果:所有的Kimba小鼠和野鼠都出现严重的眼球突出,眨眼反射消失,角膜干燥和晶状体混浊。最早的晶状体混浊发生在麻醉后的21±6min,晶状体混浊可持续150±24min。结论:氯胺酮/甲苯噻嗪麻醉可导致暂时性晶状体混浊,晶状体混浊与氯胺酮/甲苯噻嗪的副作用有关。
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| 关 键 词： | 氯胺酮 甲苯噻嗪 眼球突出 晶状体混浊 小鼠 |
Acute reversible lens opacity affects retinal HRA+OCT imaging in mice |
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| Cai Rui Li,Shu Guang Sun,Ireni Ali Rahman and Chooi May Lai. Acute reversible lens opacity affects retinal HRA+OCT imaging in mice[J]. International Eye Science, 2010, 10(1): 21-22. DOI: 10.3969/j.issn.1672-5123.2010.01.007 |
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| Authors: | Cai Rui Li Shu Guang Sun Ireni Ali Rahman Chooi May Lai |
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| Affiliation: | Cai-Rui Li1,2,Shu-Guang Sun1,Ireni Ali Rahman2,3,Chooi May Lai2,31Department of Ophthalmology,the Hospital of Dali University,Dali 671000,Yunnan Province,China 2Lions Eye Institute,Molecular Ophthalmology Department,Nedlands,Australia3Centre for Ophthalmology and Visual Science,University of Western Australia,Australia |
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| Abstract: | AIM: To assess the affect of ketamine and xylazine (ketamine/xylazine) to the transient lens opacity in mice.METHODS: Kimba mice (n=10) and wild-type mice (wt, n=8) were sedated with intraperitoneal injection of ketamine (60mg/kg for mice) and xylazine (10mg/kg) at 4, 8, 12 and 16 weeks old respectively. Pupils were dilated with tropicamide 25g/L alone to allow imaging lens status and retina using Spectralis HRA+OCT. RESULTS: All Kimba mice and wt presented extreme proptosis, suppression of the eye-blink reflex, corneal surface drying and lens opacities which occurred as early as 21±6 minutes after giving anesthesia and the lens opacities lasted up to 150±24 minutes.CONCLUSION: Ketamine/xylazine can cause transient lens opacity that may be related with the drugs side-effect. |
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| Keywords: | ketamine xylazine proptosis lens opacity mouse |
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