血、尿胱抑素C检测对小儿肺炎肾功能监测的临床研究

目的探讨小儿肺炎不同时期血、尿胱抑素C(Cys C)变化及其临床价值。方法检测120例健康人员和214例小儿肺炎患者急性期、恢复期的血、尿胱抑素C、肌酐(Cr)、微量白蛋白(MA)、α1-微球蛋白(α1-MG)等指标,并对结果进行统计处理。结果重症肺炎急性期血、尿Cys C含量均显著高于对照组(均P<0.01);恢复期与对照组比较无显著性差异(均P>0.05);重症肺炎急性期与恢复期比较,二者有显著性差异(均P<0.05);轻症肺炎急性期、恢复期与对照组比较,均无显著性差异(均P>0.05)。结论重症肺炎对小儿肾功能有不同程度的损害,但肾功能损害是可逆性的;血、尿Cys C测定对小儿早期肾功能损害的诊断、治疗及疗效判断均具有十分重要的临床指导价值。

Detection of serum and urine Cystatin C for monitoring renal function in infantile pneumonia patients

Objective To explore the changes of serum and urine cystatin C(Cys C) levels in the different periods of infantile pneumonia.Methods A total of 120 healthy subjects and 214 infantile pneumonia patients’ serum and urine cystatin C,creatinine,microalbumin,α1-microglobulin and other indicators were detected,and the results were analyzed using statistical method.Results As for severe pneumonia,both serum and urine Cys C were significantly higher in acute phase than that in recovery phase(P<0.01),but neither of them was significant difference in recovery phase compared with control group(P>0.05).As for mild pneumonia,neither of them was significant difference between acute phase and recovery phase(P>0.05).Conclusions Severe pneumonia is harmful for renal function in children,but impaired renal function is reversible.As a sensitive index of renal dysfunction,serum and urine Cys C have a very important clinical value in early detection of renal impairment.