空腹血糖联合糖化血红蛋白检测对糖尿病筛查的临床意义

目的评价联合应用空腹血糖和糖化血红蛋白(HbA1c)检测对糖尿病筛查的临床价值。方法对8669名特定人群,同时进行空腹血糖和糖化血红蛋白(HbA1c)检测,所得数据进行对比分析。结果单独以空腹血糖大于等于6.1mmol/L筛查出的糖尿病风险人群为743人,占总检测人数的8.6%;单独以糖化血红蛋白(HbA1c)大于等于6%筛查出的糖尿病风险人群为627人,占总检测人数的7.2%;联合两种检测进行筛查,以两个指标中任何一个超过切点的都筛出来,可筛查出943人,风险筛出率为10.9%;通过统计学分析,差异有统计学意义(P﹤0.01)。结论空腹血糖或糖化血红蛋白(HbA1c)单个指标进行糖尿病风险筛查,都会有一部分可疑人群无法筛出,二者联合应用,可以筛查出更多处于糖尿病风险的可疑人群。

Clinical significance of fasting plasma glucose combined with HbA1c for screening diabetes mellitus

Objective To assess the clinical validity of using fasting plasma glucose(FPG) combined with HbA1c for screening of diabetes.Methods Fasting blood glucose and HbA1c were measured simultaneously in 8669 subjects,and the results were statistically analyzed.Results A total of 743 individuals were screened out as the risk for diabetes by using the criterion of FPG≥6%,account for 8.6%(743/8669);a total of 627 individuals were screened out as the risk for diabetes by using the criterion of HbA1c≥6.1%,account for 7.2%(627/8669);a total of 943 individuals were screened out as the risk for diabetes by using the criteria of FPG≥6% or HbA1c≥6.1%,account for 10.9%(943/8669).Statistics analysis showed that there was a significant difference in detection rate using different criteria(P﹤0.01).Conclusion Some suspicious individuals maybe missed by using FPG or HbA1c alone,combination test of HbA1c with FBG can help to find more suspicious people at diabetes risk.