| Abstract: | Objective: To examine the function change of myocardial calcium transports and determined what role the change plays in cardiac dysfunction after severe burn injury in rats.Methods: The contraction and relaxation properties of the left ventricle (LV) were studied in the isolated hearts preparations of Wistar rats at 3, 8, and 24 h after a 30%TBSA (total body surface area) full-thickness burn. The calcium transport function of the sarcoplasmic reticulum (SR) was measured by the millipore filtration technique.Results: The maximal rate of LV pressure (± dp/dtmax) of the burn group was significantly lower than that of the control group (P ＜ 0.01). In addition, the calciumdependent ATPase activity and the coupling ratio of SR were also markedly depressed.Conclusions: It indicates that the decrease in the SR calcium transport function is one of the important mechanisms for the cardiac contractile dysfunction after severe burn injury. |
