成体干细胞向血管内皮细胞定向分化的研究现状

成体干细胞存在于已分化的组织器官中,具有明显的可塑性,能跨系统、跨胚层分化,在组织工程和损伤修复领域具有重要的应用价值.在血管组织工程研究领域中,成体干细胞作为种子细胞得到越来越广泛而深入的研究.目前研究表明,具有向血管内皮细胞分化的成体干细胞主要有骨髓间充质干细胞、造血干细胞、脂肪来源的干细胞以及羊膜来源的干细胞等基于此,就成体干细胞作为种子细胞在血管组织工程领域研究现状进行综述.

Oriented differentiation of adult stem cells into vascular endothelial cells

Adult stem cells identified in tissue organs possess obviously plasticity. They can differentiate into the cells in other systems and germ layers, which are known to support the continuous repair and regeneration of tissues. In the vascular tissue engineering, the research was more and more widespread and deep on adult stem cells as seed cells～ Research indicated that there are many kinds of adult stem cells which can differentiate into vascular endothelial cells, such as bone marrow mesenchymal stem cells, hematopoietic stem cells, human adipose derived stem cells, and amnion derived stem calls. Thus, this study reviewed the current situation of adult stem cells as seed cells in vascular tissue engineering.