Comparison of Hematologic and Febrile Response to Endotoxin in Man |
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| Authors: | WOLFF, SHELDON M. RUBENSTEIN, MELVIN MULHOLLAND, JOHN H. ALLING, DAVID W. |
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| Affiliation: | 1 Laboratory of Clinical Investigations, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
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| Abstract: | The infusion of endotoxin in man is followed by a fall in mononuclear cellcount and subsequent granulocytosis. Significant granulocytopenia was notobserved, nor were changes in plasma fibrinogen levels or platelet countsnoted. Although a correlation was demonstrated between dose of endotoxinadministered and hematologic response, there was no correlation between themagnitude of fever and hematologic changes. Hematologic responsivenesswas unchanged following the development of febrile tolerance to endotoxin. Submitted on September 22, 1964 Accepted on November 11, 1964 |
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