Expression of chicken interleukin-2 by turkey herpesvirus increases the immune response against Marek's disease virus but fails to increase protection against virulent challenge. |
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| Authors: | I Tarpey P J Davis P Sondermeijer C van Geffen I Verstegen V E J C Schijns Jill Kolodsick R Sundick |
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| Affiliation: | Intervet UK, Walton Manor, Walton, Milton Keynes, Bucks, MK7 7AJ, UK. ian.tarpey@intervet.com |
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| Abstract: | As Marek's disease virus continues to evolve towards greater virulence, more efficacious vaccines will be required in the future. We expressed chicken interleukin-2 (IL-2) from a turkey herpesvirus (HVT) in an attempt to increase the efficacy of HVT as a vaccine against Marek's disease. The recombinant IL-2/HVT was safe for in ovo vaccination, although it replicated less in the birds compared with the parent HVT strain. Expression of IL-2 increased the neutralizing antibody response against HVT but did not increase the protection against virulent Marek's disease virus challenge. |
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