70岁以上男性降钙素受体基因型与骨密度的关系

目的探讨老年男性降钙素受体（CTR）基因型与骨密度（BMD）的关系,及其相应的健康教育方法。方法选取年龄≥70岁的深圳地区男性59例,采用双能X线骨吸收仪（DEXA）测定BMD值,并采用聚合酶链反应-限制性长度多态性（PCR-RFLP）技术检测CTR基因型。结果59例受试者中,CTR基因型分别为CC型47例（79.66%）、CT型12例（20.34%）、TT型0例;在腰椎2-4（L2-4）和沃氏三角（Ward＇s）组BMD值,CT基因型组较CC型组低,差异有统计学意义（P〈0.05）,其他组间BMD值差异无统计学意义（P〉0.05）。结论CT基因型的男性可能容易发生原发性骨质疏松（OP）,尤其在L2-4和Ward＇s部位;应及早实施具有个体化的健康教育,防治OP及避免OP性骨折的发生。

A Study on the Correlation between Calcitonin Receptor Genotypes and Bone Mineral Density in Male Subjects Over 70 Years Old

Objective To investigate the influence of genotypes of calcitonin receptor (CTR) on bone mineral density (BMD) in male subjects. Methods 59 male subjects with an age over 70 years old were included in this study. BMD at hip and lumbar 2-4 was measured by dual energy X-ray absorptiometry (DEXA). CTR genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The distribution of CTR genotypes in these 59 subjects was 79.66% CC and 20.34% CT. No patient had the TT genotype. Patients with the CC genotype had a significantly lower value (P<0.05) of BMD than the patients with CT genotype. Conclusion Male individuals with CT genotype are at a higher risk to have osteoporosis,especially osteoporosis at L2-4 and Ward's site. Early implementation of health education may prevent osteoporosis and osteoporosis associated bone fracture.