| 逆转mdr1引起的多药耐药性的策略 |
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| 引用本文： | 张晓晓,赵晶,潘兴华,吕燕波,周亚光.逆转mdr1引起的多药耐药性的策略[J].中国医疗前沿,2009,4(18):12-13,16. |
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| 作者姓名： | 张晓晓 赵晶 潘兴华 吕燕波 周亚光 |
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| 作者单位： | [1]解放军昆明总医院干细胞与组织器官工程研究中心,昆明650032 [2]贵阳医学院药学院,贵阳550004 [3]解放军昆明总医院耳鼻咽喉科,昆明650032 |
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| 基金项目： | 全军"十一五"计划科研课题;项目 |
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| 摘 要： | 多药耐药基因1（mdr1）编码的P-糖蛋白表达的增加是肿瘤细胞多药耐药性最常见的发生机制之一。近年来以mdr1/P-糖蛋白为靶点,在蛋白质水平和基因水平上采用多种策略逆转MDR,这些研究均有较大进展,本文就目前逆转多药耐药性的研究状况进行综述。
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| 关 键 词： | 多药耐药 多药耐药基因1 P-糖蛋白 逆转 |
The Reverse Strategy of mdr1-induced multidrug resistance |
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| Institution: | ZHANG Xiao-xiao, ZHAO Jin, PAN Xing-hua, et all (1.The Research Center of Stem Cell , Tissue and Organ Engineering of Kunming General Hospital of Chengdu Military District of PLA, Kunming 650032, China; 2.School of Pharmacy, Guiyang Medical University, Guiyang550004, China) |
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| Abstract: | The overexpression of P- glycoprotein（P-gp）which coded by the multidrug resistance gene l（mdr1） is one of most commonly occurrence mechanisms of tumour cell multidrug resistance（MDR）. Inhibiting mdr1/P-gp as a method to reverse MDR has been studied extensively in.the past years. In the protein and the gene levels, the investigations have greatly progress. This paper reviewed the investigation status about the reverse of multidrug resistance. |
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| Keywords: | Multidrug resistance Mdr1 P-glycoprotein Reverse |
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