Ultra high-risk state for psychosis and non-transition: a systematic review |
| |
Authors: | Simon Andor E Velthorst Eva Nieman Dorien H Linszen Don Umbricht Daniel de Haan Lieuwe |
| |
Institution: | aUniversity Hospital of Psychiatry, University of Bern, 3010 Bern, Switzerland;bSpecialized Early Psychosis Outpatient Service for Adolescents and Young Adults, Department of Psychiatry, 4101 Bruderholz, Switzerland;cDepartment of Psychiatry, Academic Medical Centre, Meibergdreef 5, Amsterdam, Netherlands;dTranslational Medicine Neuroscience, Exploratory Development, Novartis Pharma AG, 4056 Basel, Switzerland |
| |
Abstract: | BackgroundMost effort in ultra high-risk (UHR) research has been directed at defining the clinical and neurobiological characteristics of those UHR subjects who go on to develop psychosis. The characteristics and outcome of the remaining UHR subjects have remained relatively unexplored.MethodWe performed a systematic review of clinical UHR studies to investigate whether information was available on the characteristics and outcome of UHR subjects who did not convert to psychosis.ResultsOf 2462 potentially relevant papers, 31 met inclusion criteria, i.e. 20 naturalistic and 11 intervention studies. On average 76% (range 46–92.6%) of the UHR patients made no transition to psychosis during follow-up (range 6 to 40 months). Nearly half of the studies provided no characteristics of those UHR subjects who did not develop psychosis. Six studies reported remission rates from initial UHR status (range 15.4% to 54.3%). Linear regression showed that more recent studies reported significantly lower transition rates as compared to earlier publications. An older mean age at baseline was associated with significant lower transition rates in publications with follow-ups exceeding 1 year.ConclusionsOur review illustrates that the long-term outcome of UHR subjects that do not develop psychosis is to date under-investigated. The studies reporting remission rates suggest that UHR criteria capture a non-negligible proportion of subjects that do not convert to psychosis. |
| |
Keywords: | Prodrome At-risk state Ultra high-risk Transition Remission |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|