| 环状RNA与冠心病的相关性研究 |
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| 引用本文： | 曹珍菊,李珊珊,刘航齐,李文頔,顾俊旭,孙意,苏明,贾玫.环状RNA与冠心病的相关性研究[J].中国分子心脏病学杂志,2021(1):3733-3738. |
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| 作者姓名： | 曹珍菊 李珊珊 刘航齐 李文頔 顾俊旭 孙意 苏明 贾玫 |
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| 作者单位： | 北京大学人民医院检验科 |
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| 基金项目： | 首都临床特色应用研究(Z181100001718156)。 |
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| 摘 要： | 目的 研究新的环状RNA hsa_circ_0009590,hsa_circ_0003302、hsa_circ_0023903与冠心病(CHD)的相关性以及hsa_circ_0043813基因的单核苷酸多态性位点(SNP)位点rs2293152与心梗风险的相关性.方法 提取14例冠心病患者及14例对照组的外周血RNA,...
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| 关 键 词： | 冠心病 环状RNA 单核苷酸多态性 |
Relationship between Coronary heart Disease and circRNA |
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| CAO Zhen-ju,LI Shan-shan,LIU Hang-qi,LI Wen-di,GU Jun-xu,SUN Yi,SU Ming,JIA Mei.Relationship between Coronary heart Disease and circRNA[J].Molecular Cardiology of China,2021(1):3733-3738. |
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| Authors: | CAO Zhen-ju LI Shan-shan LIU Hang-qi LI Wen-di GU Jun-xu SUN Yi SU Ming JIA Mei |
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| Institution: | (Department of Clinical laboratory,Peking University People's Hospital,Beijing 100044,China) |
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| Abstract: | Objective To explore the relationship between hsacirc0003302,hsacirc0009590,hsacirc0023903,rs2293152 and coronary heart disease.Methods A total of 14 coronary heart disease(CHD)patients and 14 control patients were recruited,the expression of hsacirc0009590,hsacirc0029303 and hsacirc0003302 were detected by real-time qPCR assay.The relationship between rs2293152 and myocardial infarction(MI)were detected with PCR-restriction fragment length polymorphism(PCR-RFLP)assay.Results There were no significant differences in the expressions of hsacirc0009590,hsacirc0029303 and hsacirc0003302 between CHD and the control group(P>0.05).The genotype distribution or allele frequency of rs2293152 were comparable between MI group and control group(P>0.05).Conclusion hsacirc0009590,hsacirc0029303 and hsacirc0003302 may not correlate with risk of CHD,and SNP site rs2293152 may not correlate with risk of MI in CHD patients. |
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| Keywords: | Coronary heart disease circRNA SNP |
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