| CXXC锌指蛋白1在恶性肿瘤中的研究进展 |
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| 引用本文： | 王东升,穆思宇,王健岗,谢龙飞,钟翔宇.CXXC锌指蛋白1在恶性肿瘤中的研究进展[J].中国比较医学杂志,2021(3). |
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| 作者姓名： | 王东升 穆思宇 王健岗 谢龙飞 钟翔宇 |
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| 作者单位： | 哈尔滨医科大学附属第二医院胆胰外科 |
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| 摘 要： | CXXC锌指蛋白1(CXXC finger protein-1,CFP1)是一种表观遗传调控因子,在哺乳动物细胞内参与DNA甲基化和组蛋白修饰。研究表明CFP1的失调影响细胞的基因表达、DNA损伤修复、信号转导、增殖、分裂、分化等,与恶性肿瘤的发生发展、治疗及不良预后密切相关。本文简要综述CFP1的基本功能及在恶性肿瘤中的研究进展,以期为后续研究新的肿瘤标志物和潜在的治疗靶点提供依据。
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| 关 键 词： | CXXC1 H3K4me3 DNMT1 恶性肿瘤 表观遗传学 |
Research progress on the role of CXXC zinc finger protein 1 in malignant tumors |
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| WANG Dongsheng,MU Siyu,WANG Jiangang,XIE Longfei,ZHONG Xiangyu.Research progress on the role of CXXC zinc finger protein 1 in malignant tumors[J].Chinese Journal of Comparative Medicine,2021(3). |
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| Authors: | WANG Dongsheng MU Siyu WANG Jiangang XIE Longfei ZHONG Xiangyu |
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| Institution: | (the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China) |
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| Abstract: | CXXC zinc finger protein-1(CFP1)is an epigenetic regulator involved in DNA methylation and histone modification in mammalian cells.Studies have shown that the disorder of CFP1 affects gene expression,DNA damage repair,signal transduction,proliferation,division and differentiation of cells,and is closely related to the occurrence,development,treatment and poor prognosis of malignant tumors.This paper provides a brief review of the basic function of CFP1 and research progress on its role in malignant tumors to provide the basis for follow-up research on new tumor markers and potential therapeutic targets. |
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| Keywords: | CXXC1 H3K4me3 DNMT1 malignant tumor epigenetics |
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