炎性细胞在动脉粥样硬化中作用的研究进展

心血管疾病(CVD)严重威胁人类的健康,动脉粥样硬化(As)作为CVD的重要病理基础,是氧化脂质在血管壁沉积引起的一种慢性免疫炎性病变。各种免疫炎性细胞在As的发生发展中起关键作用,因此不断探索免疫细胞在病变中的作用机制,对研究CVD的治疗策略是至关重要的。本文主要对中性粒细胞、单核细胞、淋巴细胞、树突状细胞、肥大细胞在As中的作用进行综述。

Progress on the role of inflammatory cells in atherosclerosis

Cardiovascular disease(CVD)is a serious threat to human health.Atherosclerosis(As),as an important pathological basis of CVD,is a chronic immune inflammatory disease caused by the deposition of oxidized lipid in the vascular wall.Various immune inflammatory cells play a key role in the occurrence and development of As,so it is very important to explore the mechanism of immune cells in the pathological changes to study the treatment strategy of CVD.In this paper,the functions of neutrophils,monocytes,lymphocytes,dendritic cells and mast cells in As are reviewed.