非糖尿病人群空腹血糖水平对动脉僵硬度进展的影响

目的 探讨非糖尿病人群基线空腹血糖水平与动脉僵硬度进展的关联.方法 本研究选取了在2010-2018年完成了两次臂踝动脉脉搏波传导速度(baPWV)测量且第一次baPWV测量时为非糖尿病的开滦研究队列人群作为观察对象.采用多元线性回归方法,分析基线空腹血糖对随访baPWV和随访期间baPWV进展的影响.结果 符合纳入标...

Effect of fasting blood glucose on the progression of arterial stiffness in non-diabetic population

Objective To investigate the relationship between baseline fasting blood glucose level and the progression of arterial stiffness in non-diabetic population.Methods In this research,the individuals participated in the Kailuan research cohort and completed two tests of brachial-ankle pulse wave velocity(baPWV)from 2010 to 2018 and were not diabetic at the first baPWV testing were included.Multiple linear regression was applied to analyze the impact of baseline fasting blood glucose level on baPWV and its progress during the follow-up.Results A total of 16875[10453 males(61.9%)]subjects met the inclusion criteria.The average age at baseline(the first baPWV measurement)was(45.9±13.0)years old and the average baPWV was(1439.0±309.3)cm/s.During the follow-up(the second baPWV measurement),the average age was(49.6±13.3)years old,and the average baPWV was(1494.6±334.3)cm/s.The baPWV progression in the observed subjects was(55.7±233.4)cm/s.After adjusted for other confounding factors,multiple linear regression analysis found that there was a positive correlation between the baseline fasting blood-glucose level and the follow-up baPWV.With every 1 mmol/L baseline fasting blood-glucose increase,the follow-up baPWV increased 16.89 cm/s.With every 1 mmol/L fasting blood-glucose level increase,the progress of baPWV increased 3.70 cm/s.Conclusions Fasting blood glucose levels in non-diabetics affect arterial stiffness during follow-up.Elevated fasting blood glucose levels during the follow-up period are risk factors that affect the progression of arterial stiffness.