阿托伐他汀药物在脑卒中高危人群中应用的效果研究

目的:通过有效的阿托伐他汀药物干预,探讨药物在卒中发病前及脑细胞并未处于完全性缺血缺氧状态下给予有效干预措施的效果.方法:于2017年4-6月,在上海市青浦区选择人口密度、经济水平相当但不相邻的2个社区60岁以上老年人进行高危险因素调查,筛选出至少具有2种危险因素的暴露人群,并对其进行颈动脉B超检查,筛选出颈动脉斑块的...

Study on the Effect of Atorvastatin in the High-risk Cases of Stroke

OBJECTIVE Through effective atorvastatin drug intervention,it explored the effect of effective interventions before the onset of stroke and the brain cells were not in a state of complete ischemia and hypoxia.METHODS From April to June 2017,two groups of 60-year-old people with similar population density and economic level but not adjacent were selected as the target group in Qingpu District to conduct a high risk factor survey.It screened out the exposed population with at least two risk factors,and performed a carotid ultrasound examination.217 people with carotid plaques were selected as key observation objects,1 community was the intervention group(108 cases),oral Lipitor and aspirin drugs,1 community was the control group(109 cases),only taking aspirin drugs as intervention methods.The intervention period was two years.Before and after the intervention,blood lipid test and carotid atherosclerosis plaque test were performed to compare the changes of blood lipid and carotid plaque intima-media thickness before and after treatment.RESULTS TC,LDL-C,HDL-C in the intervention group were significantly improved compared with the control group,70.4%of hyperlipidemia in the intervention group was returned to normal blood lipids,and only 18.5%of hyperlipidemia in the control group was returned to normal;70.4%of the hyperlipidemia in the intervention group returned to normal blood lipids,while only 18.5%of the hyperlipidemia in the control group returned to normal;IMT intimal thickening occurred in 31.3%of the cases;9.2%of the subjects in the intervention group developed from unilateral plaque to bilateral plaque,and 21.2%of the control group developed from unilateral plaque to bilateral plaque.The difference was statistically significant.CONCLUSION Lipitor could be effectively used as an intervention measure for high-risk cases of carotid atherosclerotic plaque stroke,supplemented by Doppler ultrasound to observe plaque changes before and after intervention.With advantages of strong operability,good repeatability,and easy to popularize,Lipitor would play a greater role in the prevention and treatment of ischemic stroke.