舒芬太尼在上腹部手术后静脉自控镇痛中的临床应用

目的探讨舒芬太尼用于上腹部手术后病人静脉自控镇痛(PCIA)的有效性及安全性。方法选择90例上腹部择期手术病人,随机分为3组,每组30例,术后静脉镇痛分别使用舒芬太尼1.5μg/ml(A组)、舒芬太尼1.0μg/ml(B组)及芬太尼10μg/ml(C组)。记录术后第4、8、20、24、48小时的镇痛效果,镇静程度,恶心呕吐反应及血氧饱和度,呼吸频率,病人自控按压次数等数据。结果与B、C组比较,A组VAS评分降低,差异有显著性,B、C组比较,VAS评分差异无显著性。结论舒芬太尼适用于上腹部手术后PCIA。镇痛效果好,副作用小,其1.5ug/ml浓度则更佳。

Clinical Application of Sufentanil in Postoperative Patient-controlled Intravenous Analgesia for Patients with Upper Abdominal Surgery

Objective To compare the clinical effect and safety of different concentration of sufentanil for patient-controlled intravenous analgesia(PCIA) after upper abdominal surgery.Methods Ninety patients undergoing upper abdominal surgery were assigned with random and double-blind method to three groups for receiving PCIA with sufentanil 1.5μg/ml(group A,n=30),sufentanil 1.0μg/ml(group B,n=30) and fentanyl 10 μg/ml(group C,n=30).Visual analogue scales(VAS),sedation,side-effects including nausea and emesis,SPO2,respiration rate and pressure times were assessed after the 4th,8th,12th,20th and 48th hour of postoperative analgesia.Results After 48h of postoperative analgesia,VAS scores in group A were lower than that in group B and C(p<0.05).VAS scores in group B and C were equivalent(p>0.05).Conclusions Sufentanil is suitable for PCIA after upper abdominal surgery,the side-effects is small and the dose of sufentanil 1.5ug/ml can obtained a better postoperative analgesia.