| 痰热清氯化钠注射液指纹图谱的研究 |
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| 引用本文： | 宋汉敏,刘乃强,刘素梅,聂桂华.痰热清氯化钠注射液指纹图谱的研究[J].中草药,2007,38(9):1320-1323. |
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| 作者姓名： | 宋汉敏 刘乃强 刘素梅 聂桂华 |
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| 作者单位： | 1. 河南省食品药品检验所,河南,郑州,450003
2. 河南省兽药监察所,河南,郑州,450008 |
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| 摘 要： | 目的建立痰热清氯化钠注射液的指纹图谱。方法采用HPLC-ELSD法检测痰热清注射液中非挥发性成分,以黄芩苷对照品为参照,标定共有峰,计算相对保留时间和相对峰面积比值,确定10批样品之间的相似度。结果在全面方法学研究的基础上,对10批痰热清氯化钠注射液进行检测分析,HPLC指纹图谱有16个共有峰,其相对保留时间及相对峰面积比值均符合要求。结论建立的指纹图谱可作为痰热清氯化钠注射液质量评价的重要依据之一。
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| 关 键 词： | 痰热清氯化钠注射液 黄芩苷 高效液相色谱 指纹图谱 |
| 文章编号： | 0253-2670（2007）09-1320-04 |
| 收稿时间： | 2006/11/1 0:00:00 |
| 修稿时间： | 2006-11-01 |
Chromatographic fingerprint of Tanreqing NaCI Injection |
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| SONG Han-min,LIU Nai-qiang,LIU Su-mei and NIE Gui-hua.Chromatographic fingerprint of Tanreqing NaCI Injection[J].Chinese Traditional and Herbal Drugs,2007,38(9):1320-1323. |
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| Authors: | SONG Han-min LIU Nai-qiang LIU Su-mei and NIE Gui-hua |
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| Institution: | 1. Henan Institute for Food and Drug Control, Zhengzhou 450008, China; 2. Henan Institute for Animal Drug Control, Zhengzhou 450008, China |
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| Abstract: | Objective To establish the fingerprint detecting standard for Tanreqing NaCl Injection. Methods Using baicalin as reference substance to calibrate the common peaks by HPLC-ELSD. According to the technical requirements on fingerprint of traditional Chinese medicine injection, their relative retention times and peak area ratios were calculated and the similarity of ten batchs of samples was determined. Results On the basis of systematic methodology, ten batches of injection samples were tested and analyzed so as to establish HPLC fingerprint for the injection. Conclusion The relative retention times and peak area ratios of 16 common peaks on HPLC fingerprint all conform to the requirement. So the established fingerprint can be used as the one of important foundations for quality control of Tanreqing NaCl Injection. |
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| Keywords: | Tanreqing NaCl Injection baicalin HPLC fingerprint |
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