腺泡状软组织肉瘤28例临床病理分析

目的探讨腺泡状软组织肉瘤(ASIS)的临床病理特征及鉴别诊断。方法对28例ASPS进行HE染色，光镜观察，其中18例做组化(PAS)和免疫组化(SP法)染色。结果28例腺泡状软组织肉瘤中，男性19例，女性9例；年龄2～55岁，平均29．5岁；病变主要位于下肢深部骨骼肌组织内。组织学可见瘤组织呈特征性的腺泡或巢团样排列，胞质内可见嗜伊红颗粒及结晶体，PAS染色( )。免疫组化：18例中，5例S-100蛋白弥漫( )，3例NSE局灶( )，3例Vim局灶( )，desmin、SMA、EMA、Myo、aetin和CK均(一)。结论腺泡状软组织肉瘤多见于年轻男性，结合临床和病理特征，可作出正确的病理诊断。

Alveolar soft part sarcoma:a clinicopathological analysis of 28 cases

Objective To investigate the clinical pathological features and differential diagnosis of alveolar soft part sarcoma(ASPS). Methods 28 cases of ASPS were studied using HE staining, of which 18 cases were also studied using PAS staining and immunohistochemistry (SP method). Results The patients were 19 male and 9 female, aged from 2 to 55 years old (mean 29 5 years). The lesions were mainly located in the deep skeletal muscles of the lower limbs. Histologically, the tumor showed typical alveolus and nest arrangement, there were esinophilic granules and crystals in cytoplasm of the tumor cells. 18 cases were positive for PAS staining. Immunohistochemically, 5 cases were diffusely positive for S\|100, 3 cases were spot positive for NSE and 3 cases were spot positive for vimentin, but desmin, SMA, EMA, Myo, actin and CK were all negative in all cases. Conclusion ASPS is a disease which is most commonly involved in young male. By combining with clinical and pathological features we can make a correct pathological diagnosis.