Immunoglobulin A (IgA) deposits in lesional skin of a patient with blepharochalasis |
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Authors: | A. GRASSEGGER N. ROMANI P. FRITSCH J. SMOLLE H. HINTNER |
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Affiliation: | Department of Dermatology, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria;Department of Dermatology, University of Graz, Austria;Department of Dermatology, General Hospital Salzburg, Austria |
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Abstract: | Summary We describe a 21-year-old male patient with blepharochalasis, a form of localized acquired cutis laxa. He had a 13-year history of recurrent swelling attacks of the eyelids of unknown origin leading to periocular localized cutis laxa. Histology of lesional skin confirmed almost complete loss of elastic fibres in the reticular and papillary dermis. Immunofluorescence and immunoelectron microscopy studies showed abundant immunoglobulin A (IgA) deposits around the remaining elastic fibres. Control skin of the forearm was negative. These findings support the hypothesis that immunopathogenetic mechanisms may contribute to the elastolytic process of blepharochalasis. |
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