电针足三里穴对胃粘膜保护作用的机制研究

目的]探讨电针足三里穴对胃粘膜的保护作用机制。方法]将20只狗随机分为空白对照组、非经非穴组、上巨虚组、足三里组（每组5只）。采用激光多普勒血流仪连续监测狗胃粘膜血流量的变化，同步测定血浆及胃粘膜组织中降钙素基因肽（CGRP）含量，并观察其变化规律。结果]电针足三里穴可使狗胃粘膜血流量增加（与针刺前比P＜0.05或P＜0.01），使血浆和胃体粘膜中的CGRP含量增加（P＜0.05或P＜0.01)；而针刺上巨虚穴有同样的作用趋向，但未显示统计学意义；针刺非经非穴组未见这一变化。结论]说明电针足阳明胃经穴位，尤其电针足三里穴可以改善胃粘膜的血流量，这种改善可能与针刺影响血浆和胃粘膜的CGRP含量升高有关，这可能也是电针足三里可以对胃粘膜起保护作用的机制之一。

Mechanism of Electroacupuncture of Zusanli in Protecting Gastric Mucosa of Dogs

To explore the mechanism of electroacupunture (EA) of Zusanli (ST36)in protecting gastric mucosa of dogs.Twenty mongrel dogs were randomly allocated to four groups: blank control group (Group A), non acupoint group (Group B), Shangjuxu (ST37) group (Group C) and Zusanli (ST36) group (Group D). Dynamic gastric mucosal blood flow (GMBF) was monitored by laser Doppler flowmeter and calcitonin gene related peptide (CGRP) contents in plasma and gastric mucosa were measured simultaneously by radioimmunoassay method. After sixty minutes of EA, GMBF and CGRP contents in plasma and gastric mucosa were increased in Group D (P<0 05 or P<0 01 as compared with those before EA). In Group C, plasma CGRP content was also increased but the ascending velocity was not so obvious and no significant difference was found in gastric mucosal CGRP content and GMBF. No obvious changes of the observing indexes were found in Group A and Group B.Conclusion]EA of Zusanli (ST36) can increase GMBF and CGRP contents in plasma and gastric mucosa while no significant changes were found in Shangjuxu (ST37) group, blank control group and non acupoint group. This indicates that EA of acupoints of the Stomach Meridian of Foot Yangming, especially of Zusanli (ST36), can improve GMBF, which may be related to the effect of EA on CGRP contents in plasma and gastric mucosa and this may be one of the mechanisms of EA of Zusanli (ST36) in protecting gastric mucosa of dogs.