VEGF-C与胃癌淋巴管新生临床病理因素的关系

目的：研究血管内皮生长因子C（VEGF-C）与胃癌淋巴管新生及其临床病理因素的关系。方法：收集65例胃癌患者围手术期一般临床资料和病理学资料，并进行随访。分析VEGF-C免疫组织化学表达与肿瘤组织淋巴管密度（LVD）计数的关系；对随访的54例患者作生存分析。结果：胃癌组织VEGF-C阳性表达率明显高于正常胃组织（P〈O，05）；胃癌组织VEGF-C阳性组、阴性组LVD计数分别为16．14±511、1011±4．55，两者差异具有统计学意义（P〈0．01）；VEGF-C的表达及LVD计数与胃癌直径、大体类型、Lauren分型、年龄、性别、饮食、区域分布无明显相关；而与肿瘤分化程度、浸润深度、淋巴结转移、远处转移及TNM分期呈正相关（P〈O．05）。胃癌组织VEGF-C阳性表达组1、2,3年复发率分别为40．1％、66．7％、79，2％，阴性表达组则分别为27。4％、31．3％、45．7％。VEGF-C阳性组1、2、3年复发率明显高于VEGF-C阴性组（P〈O．01）；54例随访患者，VEGF-C8t3,1~患者总体生存率明显低于VEGF-C阴性患者（P〈0．01）。结论：VEGF-C在胃癌淋巴管新生中起重要作用，其表达阳性率可作为胃癌术后一个新的预后指标。

Vascular endothelial growth factor-C and lymphangiogenesis in gastric carcinoma and its clinicopathological features

Objective: To research on vascular endothelial growth factor-c(VEGF-C) relationship between lymphangiogenesis in gastric cancer and clinical pathological features of.Methods: Collection of 65 cases with gastric cancer during perioperative period in patients with clinical and pathological information and follow-up.Analysis of immunohistochemical expression of lymphatic vessel density and tumor VEGF-C(1ymphatic vessel density,LVD) count;on a survival analysis of 54 cases in the follow-up of patients.Results: VEGF-C positive rates significantly higher than normal gastric cancer gastric tissue(P<0.05).Negative expression of VEGF-C-positive gastric cancer tissue expression group,group of LVD counts were 16.14±5.11,10.11±4.55,difference between statistical significance(P<0.01).The size,type of VEGF-c expression and gastric cancer,Lauren,age,sex,diet,no clear relevance of regional distribution.Expression of VEGF-c group-positive gastric cancer recurrence rate of 1 year,2 year,3 year,40.1%,66.7%,79.2%,respectively,Expression of VEGF-c-negative gastric cancer group,27.4%,31.3%,45.7%,respectively.TP positive HCC Group 2-year,3-year relapse rate significantly higher than the TP-negative group(P<0.01).In 54 cases with follow-up,VEGF-C-positive Group overall survival rates significantly lower than the negative group(P<0.01).Conclusion: VEGF-C played an important role in the new biochemical lymphatic vessels in gastric cancer,Positive rate of expression can be used a new indicators of prognosis of gastric cancer after operation.