| 黄连素对小鼠实验性血栓形成的影响 |
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| 引用本文： | 李淑秀,朱玉翠.黄连素对小鼠实验性血栓形成的影响[J].河南医学研究,1994,3(1):43-45. |
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| 作者姓名： | 李淑秀 朱玉翠 |
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| 作者单位： | 郑州市卫生学校，河南医科大学卫生学校，河南医科大学第一附属医院 |
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| 摘 要： | 雄性小白鼠５６只，分４组，每组１４只。花生四烯酸（ＡＡ）组，于尾静脉注入ＡＡ０．５ｍｇ；黄连素＋ＡＡ组，灌喂黄连素０．５ｍｇ（２０ｍｇ／ｋｇ）；阿司匹林＋ＡＡ组，灌喂阿司匹林０．５ｍｇ（２Ｏｍｇ／ｋｇ）；生理盐水＋ＡＡ组，灌喂生理盐水０．５ｍｌ。每日１次，连续三日后尾静脉注射ＡＡ０．５ｍｇ。以上分期分批处死。见ＡＡ组心、肺出现血小板血栓者１３只、１４只，占９２．９％～１００％，黄连素＋ＡＡ组为５只，占３５．７％，与ＡＡ组相比，Ｐ＜０．００５；阿司匹林＋ＡＡ组为６只，占３２．９％，与黄连素＋ＡＡ组相比，Ｐ＞０．５，无明显差别。故认为黄连素与阿司匹林相似，也对ＡＡ所致的血小板血栓有抑制作用，值得进一步研究并于临床应用。
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| 关 键 词： | 黄连素，阿司匹林，花生四烯酸（AA），血栓形成 |
TBE EFFECTS OF BERBERINE ON EXPERIMENTAL MICE THROMBOSIS |
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| LiShu-Xiu et al.TBE EFFECTS OF BERBERINE ON EXPERIMENTAL MICE THROMBOSIS[J].Henan Medical Research,1994,3(1):43-45. |
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| Authors: | LiShu-Xiu |
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| Abstract: | Fifty-six male mice were divided into four groups each of which consists of14;①the arachidonic acid(AA)group,②the berberine+AA group,③the aspirin+AAgroup,④the normal saline+AA group.The results;The platelets thrombus were respective-ly found 13 mice(95%)in the AA group,5 mice(36%)in the berberine+AA group(P<0.005,compared with the AA group)and 6 mice(43%)in the aspirin+AA group(P<0.005,compared with the AA group). The results suggest that the berberin and the aspirinhave the similar function of inhibiting the platelets thrombosis. |
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| Keywords: | berberine aspirin arachidonic acid thrombosis |
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