|
|||||
|
|
Immunohistochemical expression of N-ras oncogene is a late event in head and neck carcinomas |
|
| Authors: | John S McDonald Keith M Wilson Peter Gartside Robert L Sonkk Ljiljana Pavelic Eric Okum Julie Neanen Jack L Gluckman Zlatko P Pavelic |
| Institution: | (1) Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio;(2) Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio;(3) Medical School, Ohio State University, Columbus, Ohio;(4) Division of Molecular Oncology, Department of Otolaryngology-Head and Neck Surgery, College of Medicine, University of Cincinnati, 45167-0528 Cincinnati, Ohio, USA |
| Abstract: | This study investigated the expression of the N-ras oncogene in routinely processed tissue sections from 133 patients with squamous cell carcinoma of the head and neck (SCCHN) by immunohistochemistryusing anti-N-ras monoclonal antibody. N-ras expression was present in 67 of 133 (49.67%) cases. There was a highly significant correlation between N-ras expression and clinical stage of disease (P=0.003). This study confirmed that overexpression of the N-ras oncogene is common in SCCHN and that it may be an important event in the late stage of disease. |
| Keywords: | head and neck cancer immunohistochemistry N-ras |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |